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Metabolomics Interdisciplinary Lab (MiL@b)

NUTRITION AND METABOLISM
NUTRICIÓ DIABETIS OBESITAT COLESTEROL
http://metabolomicsplatform.com/
TARGETS

The Metabolomics Platform (PM), created in 2007, is a joint research infrastructure between CIBERDEM and the Rovira i Virgili University (URV) for the provision of technological services in the field of metabolomics. The PM is also part of the IISPV. The main objective is to work as a laboratory integrated by the CIBERDEM groups, the CIBER centers and the IISPV, helping them to design the metabolomics experiments, perform the experiments, process the data and evaluate the results.

RESPONSIBLE

  • Xavier Correig Blanchar

  • Presentation
  • Lines
  • Group members
  • Projects / Grants
  • Media / Xarxes
  • Publications
  • Contact

PM has access to state-of-the-art analytical equipment in mass spectrometry and nuclear magnetic resonance, which allow large-scale analysis of biological samples. The use of advanced statistics, chemometry, and multivariate algorithms allows a high set of experimental data to be transformed into metabolic profiles and ultimately into clinical information. The experimental data are processed by the platform team, facilitating the interpretation of the results and providing solid, relevant and useful clinical conclusions for the different research groups.

  • Processing of metabolomics data and identification of metabolites by LC-MS and GC-MS. Integration of omic technologies.
  • Labeling of stable isotopes and fluxomics by MS and NMR.
  • Unmarked spectrometry images for biological applications.
  • Advanced processing and analysis of metabolomics data for analytical techniques and multidimensional clinical applications.
  • Metabolomics by NMR.
  • Toxicological and environmental metabolism.

  • Títol: AYUDAS JUAN DE LA CIERVA – INCORPORACION 2015
    Referència: IJCI-2015-23158
    Entitat finançadora: Instituto de Salud Carlos III
    Durada: 01/09/2017 – 31/08/2019

  • Títol: TYPE OF ACTION: RELIABLE AND SPECIFIC URINARY BIOMARKERS FOR COLORECTAL CANCER (COLOVOC)
    Referència: H2020-MSCA-IF-2017; PROPOSAL NUMBER: 798038
    Entitat finançadora: MARIE CURIE HORIZON 2020
    Durada: 01/09/2017 – 30/06/2022

  • Títol: ESTANCIAS DE MOVILIDAD EN EL EXTRANJERO ‘JOSE CASTILLEJO’ PARA JOVENES DOCTORES
    Referència: —
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 08/07/2019 – 30/09/2019

  • Títol:
    Referència: EIN2019-102898
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 01/06/2019 – 31/05/2020

  • Títol: EPIGENETIC AND METABOLIC ALTERATIONS ASSOCIATED TO EARLY CHILDHOOD EXPOSURE TO AIR POLLUTION AND ITS ROLE IN LATER LIFE CHRONIC DISEASE (ECHOES)
    Referència:
    Entitat finançadora: RECERCA SOCIAL “LA CAIXA”
    Durada: 01/01/2020 – 31/12/2021

  • Títol: Development of a signal and data processing workflow for 2D
    hyphenated chromatography based on multi-way algorithms: Application to urine metabolomics data for colorectal cancer screening (TensorChrom)
    Referència:
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 01/01/2019 – 31/12/2022

  • Títol: Desarrollo de nuevas tecnologías de histología molecular basadas en espectroscopia de imágenes y su aplicación al estudio del cáncer y la diabetes (hisMOL4CANdia)
    Referència:
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 01/01/2019 – 31/12/2022

  • Títol Ayudas Juan de la Cierva-incorporación
    Referència: IJCI-2017-33438
    Entitat finançadora: Ministerio de Economía y Competitividad
    Durada: 01/01/2019 – 31/12/2021

  • CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM). (CB07/08/0014)

  • RED ESPAÑOLA DE METABOLÓMICA

    Year

    Lipid Profiling Using (1)H NMRSpectroscopy

    Gil M, Samino S, Barrilero R, Correig X
    Methods Mol Biol
    2019;2037:35-47
    10.1007/978-1-4939-9690-2_3

    Gelsolin: a new biomarker of disease activity in SLE patients associated with HDL-c

    Parra S, Heras M, Herrero P, Amigó N, Garcés E, Girona J, Correig X, CanelaN, Castro A
    Rheumatology (Oxford)
    10.1093/rheumatology/kez293

    Plasma glucose, triglycerides, VLDL,leptin and resistin levels asPotential biomarkers for myocardial fat in mice

    Rodríguez-Calvo R, Samino S, Guaita-Esteruelas S, Martínez-Micaelo N, HerasM, Girona J, Yanes O, Correig X, Masana L
    Clin Investig Arterioscler
    10.1016/j.arteri.2019.05.001

    Gold Nanoparticle-Assisted Black Silicon Substrates for Mass Spectrometry Imaging Applications

    Iakab SA, Ràfols P, Tajes M, Correig-Blanchar X, García-Altares M.
    ACS Nano. 2020 Jun 23;14(6):6785-6794.
    DOI: 10.1021/acsnano.0c00201

     

    Activation of glycogenolysis and glycolysis in breast cancer stem cell models

    Abad E, Samino S, Yanes O, Potesil D, Zdrahal Z, Lyakhovich A.
    Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165886.
    DOI: 10.1016/j.bbadis.2020.165886

     

    rMSIproc: an R package for mass spectrometry imaging data processing

    Ràfols P, Heijs B, Del Castillo E, Yanes O, McDonnell LA, Brezmes J, Pérez-Taboada I, Vallejo M, García-Altares M, Correig X.
    Bioinformatics. 2020 Jun 1;36(11):3618-3619.
    DOI: 10.1093/bioinformatics/btaa142

     

    Raman2imzML converts Raman imaging data into the standard mass spectrometry imaging format

    Iakab SA, Sementé L, García-Altares M, Correig X, Ràfols P.
    BMC Bioinformatics. 2020 Oct 9;21(1):448.
    DOI: 10.1186/s12859-020-03789-8

    Endogenous retroelement activation by epigenetic therapy reverses the Warburg effect and elicits mitochondrial-mediated cancer cell death

    Fresquet V, Garcia-Barchino MJ, Larrayoz MJ, Celay J, Vicente C, Fernandez-Galilea M, Larrayoz MJ, Calasanz MJ, Panizo C, Junza A, Han J, Prior C, Fortes P, Pio R, Oyarzabal J, Martínez-Baztán A, Paiva B, Moreno-Aliaga MJ, Odero MD, Agirre X, Yanes O, Prósper F, Martinez-Climent JA
    2020 Dec 19 [Epub ahead of print]. Cancer Discovery.
    DOI: 10.1158/2159-8290.CD-20-1065

     

    Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

    Plana-Bonamaisó A, López-Begines S, Fernández-Justel D, Junza A, Soler-Tapia A, Andilla J, Loza-Alvarez P, Rosa JL, Miralles E, Casals I, Yanes O, de la Villa P, Buey RM, Méndez A.
    Elife. 2020 Apr 7;9:e56418.
    DOI: 10.7554/eLife.56418

    Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

    Pelletier J, Riaño-Canalias F, Almacellas E, Mauvezin C, Samino S, Feu S, Menoyo S, Domostegui A, Garcia-Cajide M, Salazar R, Cortés C, Marcos R, Tauler A, Yanes O, Agell N, Kozma SC, Gentilella A, Thomas G.
    EMBO J. 2020 Jul 1;39(13):e103838.
    DOI: 10.15252/embj.2019103838

    Chemical changes in thirdhand smoke associated with remediation using an ozone generator.

    Tang X, Ramírez Gonzalez N, Russell ML, Maddalena RL, Gundel LA, Destaillats H
    2020 Nov 18 [Epub ahead of print]. Environmental Research.
    DOI: 10.1016/j.envres.2020.110462

    Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity

    Carmona-Maurici J, Amigó N, Cuello E, Bermúdez M, Baena-Fustegueras JA, Peinado-Onsurbe J, Pardina E.
    Eur J Clin Invest. 2020 Nov;50(11):e13320.
    DOI: 10.1111/eci.13320

    Habitual Fish Consumption, n-3 Fatty Acids, and Nuclear Magnetic Resonance Lipoprotein Subfractions in Women
    rMSIcleanup: an open-source tool for matrix-related peak annotation in mass spectrometry imaging and its application to silver-assisted laser desorption/ionization
    Glycoprotein Profile Assessed by (1)H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study
    Plasma Metabolomic Profiling Associates Bicuspid Aortic Valve Disease and Ascending Aortic Dilation with a Decrease in Antioxidant Capacity
    GlycA Levels during the Earliest Stages of Rheumatoid Arthritis: Potential Use as a Biomarker of Subclinical Cardiovascular Disease
    Environmental arginine controls multinuclear giant cell metabolism and formation
    Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review
    Fatty acid bindingprotein 4 (FABP4) as a potential biomarker reflecting myocardial lipid storage intype 2 diabetes

    Rodríguez-Calvo R, Girona J, Rodríguez M, Samino S, Barroso E, deGonzalo-Calvo D, Guaita-Esteruelas S, Heras M, van der Meer RW, Lamb HJ, Yanes O,Correig X, Llorente-Cortés V, Vázquez-Carrera M, Masana L
    Metabolism
    10.1016/j.metabol.2019.04.007

    Epigenetic loss of theEndoplasmicreticulum-associated degradation inhibitor SVIP induces cancer cell metabolicreprogramming

    Llinàs-Arias P, Rosselló-Tortella M, López-Serra P, Pérez-Salvia M, SetiénF, Marin S, Muñoz JP, Junza A, Capellades J, Calleja-Cervantes ME, Ferreira HJ,de Moura MC, Srbic M, Martínez-Cardús A, de la Torre C, Villanueva A, Cascante M,Yanes O, Zorzano A, Moutinho C, Esteller M
    JCI Insight
    10.1172/jci.insight.125888

    Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

    Bueno M.J., Jimenez-Renard V., Samino S., Capellades J., Junza A., Lopez-Rodriguez M.L., Garcia-Carceles J., Lopez-Fabuel I., Bolanos J.P., Chandel N.S., Yanes O., Colomer R., Quintela-Fandino M.
    Nat Commun
    10.1038/s41467-019-13028-1

    Lipid ProfileRather Than theLCAT Mutation Explains Renal Disease in FamilialLCAT Deficiency

    Lamiquiz-Moneo I, Civeira F, Gómez-Coronado D, Blanco-Vaca F,Villafuerte-Ledesma HM, Gil M, Amigó N, Mateo-Gallego R, Cenarro A
    J Clin Med
    10.3390/jcm8111860

    Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

    Llauradó G, Amigó N, Cano A, Ballesta S, Albert L, Mazarico I,Fernández-Veledo S, Pedro-Botet J, Vendrell J, González-Clemente JM
    Mol Cancer Res
    10.1158/1541-7786.MCR-18-0315

    Changes in Plasma MetaboliteConcentrations after a Low-Glycemic IndexDiet Intervention

    Hernández-Alonso P, Giardina S, Cañueto D, Salas-Salvadó J, Cañellas N,Bulló M
    Mol Nutr Food Res
    10.1002/mnfr.201700975

    CliqueMS: aComputational tool for annotating in-sourcemetabolite ions from LC-MS untargeted metabolomics data based on aCoelutionsimilarity network

    Senan O, Aguilar-Mogas A, Navarro M, Capellades J, Noon L, Burks D, Yanes O,Guimerà R, Sales-Pardo M
    Bioinformatics
    10.1093/bioinformatics/btz207

    Serum Paraoxonase-1-Related Variables andLipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect ofRadiotherapy

    Rodríguez-Tomàs E, Murcia M, Arenas M, Arguís M, Gil M, Amigó N, Correig X,Torres L, Sabater S, Baiges-Gayà G, Cabré N, Luciano-Mateo F, Hernández-Aguilera A, Fort-Gallifa I, Camps J, Joven J
    Antioxidants (Basel)
    10.3390/antiox8070213

    Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14and Creatine Metabolism

    Valli A, Morotti M, Zois CE, Albers PK, Soga T, Feldinger K, Fischer R,Frejno M, McIntyre A, Bridges E, Haider S, Buffa FM, Baban D, Rodriguez M, Yanes O, Whittington HJ, Lake HA, Zervou S, Lygate CA, Kessler BM, Harris AL
    Mol Cancer Res
    10.1158/1541-7786.MCR-18-0315

    HDL Triglycerides: A New Marker of Metabolicand Cardiovascular Risk

    Girona J, Amigó N, Ibarretxe D, Plana N, Rodríguez-Borjabad C, Heras M,Ferré R, Gil M, Correig X, Masana L
    Int J Mol Sci
    10.3390/ijms20133151

    Biological Response to Meal Ingestion: Gender Differences

    Monrroy H, Borghi G, Pribic T, Galan C, Nieto A, Amigo N, Accarino A,Correig X, Azpiroz F
    Nutrients
    10.3390/nu11030702

    Meal Enjoyment and Tolerance in Women andMen

    Monrroy H, Pribic T, Galan C, Nieto A, Amigo N, Accarino A, Correig X,Azpiroz F
    Nutrients
    10.3390/nu11010119

    CD98hc (SLC3A2) sustains amino acid and nucleotide availability forcell Cycle progression

    CD98hc (SLC3A2) sustains amino acid and nucleotide availability forcell Cycle progression
    Sci Rep
    10.1038/s41598-019-50547-9

    Glycoprotein A and B Height-to-WidthRatios as Obesity-Independent Novel Biomarkers of Low-Grade Chronic Inflammation in Women with Polycystic Ovary Syndrome (PCOS)

    Fuertes-Martín R, Moncayo S, Insenser M, Martínez-García MÁ, Luque-Ramírez M,Grau NA, Blanchar XC, Escobar-Morreale HF
    J Proteome Res
    10.1021/acs.jproteome.9b00528

    Epigenetic Regulation at the Interplay Between GutMicrobiota and Host Metabolism

    Miro-Blanch J, Yanes O
    Front Genet
    10.3389/fgene.2019.00638

    RMSIKeyIon: An Ion FilteringR Package for UntargetedAnalysis of Metabolomic LDI-MS Images

    Del Castillo E, Sementé L, Torres S, Ràfols P, Ramírez N, Martins-Green M,Santafe M, Correig X
    Metabolites
    10.3390/metabo9080162

    Dysfunctional LAT2 Amino Acid Transporter Is AssociatedWith Cataract in Mouse and Humans

    Knöpfel EB, Vilches C, Camargo SMR, Errasti-Murugarren E, Stäubli A, Mayayo C, Munier FL, Miroshnikova N, Poncet N, Junza A, Bhattacharya SS, Prat E, BerryV, Berger W, Heon E, Moore AT, Yanes Ó, Nunes V, Palacín M, Verrey F,Kloeckener-Gruissem B
    Front Physiol
    10.3389/fphys.2019.00688

    Low-densityLipoprotein net charge is a risk factor foratherosclerosis inLupus patients independent ofLipid concentrations

    Rodríguez M, Guardiola M, Oliva I, Carles Vallvé J, Ferré R, Masana L, ParraS, Ribalta J, Castro A
    Int J Rheum Dis
    10.1111/1756-185X.13445

    Silicon-Based Laser Desorption Ionization Mass Spectrometry for the Analysis of Biomolecules: A Progress Report

    Iakab S.A., Rafols P., Garcia-Altares M., Yanes O., Correig X.
    Advance Functional Material
    https://doi.org/10.1002/adfm.201903609

Team Members

  • Group leader

    • Xavier Correig Blanchar

  • Senior researcher

    • Nicolau Cañellas Alberich
    • Oscar Yanes Torrado
    • Jesús Brezmes Llecha
    • Noelia Ramírez González
    • Maria Vinaixa Crevillent
    • Raquel Cumeras
    • Pere Ràfols Soler
    • Esteban Del Castillo Pérez

  • Technician

    • Pineda Molas Porqueras
    • Josep Mª Badia Aparicio
    • Laura Massó Estradé
    • Miriam Navarro Sanz

  • Postdoctoral Researcher

    • Jordi Capellades Tomàs
    • María García-Altares Pérez

  • PhD student

    • Joan Miró
    • Carla-Melissa Merino
    • Alexandra Iakab
    • Sònia Torres
    • Gerard Baquer Gómez
    • Lluc Sementé Fernández
    • Maria Llambrich Rodriguez

  • Internship student

    • Roger Giné Bertomeu

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