OBJECTIUS

El grup de recerca en Nutrigenòmica té com a objectiu general la generació de coneixement orientat al disseny d’aliments funcionals capaços de prevenir, endarrerir o pal·liar malalties metabòliques com l’obesitat, la diabetis, la hipertensió i la síndrome metabòlica. A més a més, aquests estudis també permeten la revalorització de subproductes de la industria alimentària mitjançant l’obtenció d’ingredients funcionals.

RESPONSABLES
  • Begoña Muguerza

  • Línies
  • Membres del grup
  • Projectes
  • Membres del grup+
  • Publicacions
  • Transferència
  • Publicacions+
  • Contacte
  • Avaluació dels efectes beneficiosos dels compostos fenòlics sobre patologies relacionades amb la síndrome metabòlica amb especial atenció als polifenols
  • Desenvolupament d’un aliment integral per a la pèrdua de pes corporal i la prevenció de patologies associades a l’obesitat
  • Influència dels ritmes biològics en l’efecte d’ingredients bioactius
  • Estudi de la interacció entre compostos bioactius i microRNAs
  • Obtenció i purificació de pèptids bioactius
  • Cerca de compostos bioactius amb capacitat de modular la microbiota
  • Valorització de subproductes de la industria agroalimentària

  • ESTUDIO DE LA INTERACCIÓN DE LOS RITMOS CIRCADIANOS Y ESTACIONALES CON LA EFECTIVIDAD DE LOS INGREDIENTES FUNCIONALES
    AGL2016-77105-R
    Begoña Muguerza, Anna Arola
    Duració 2016 – 2019
    Ministerio de Economía, Industria y Competitividad (MINECO)

  • DESARROLLO Y VALIDACIÓN DE UNA BEBIDA FUNCIONAL PARA EL CONTROL DE LA PRESIÓN ARTERIAL- HYPERGRAPES (RETOS)
    RTC-2017-6044-2
    Begoña Muguerza, Francisca I. Bravo
    Duració 2018 – 2021
    Ministerio de Ciencia, Innovación y Universidades

  • IDENTIFICACIÓN DE METABOLITOS DERIVADOS DE BACTERIAS QUE ACTIVAN A RECEPTORES ACOPLADOS A PROTEÍNA G (GPCR)
    Francisca I. Bravo
    Duració 2019 -2019
    Ministerio de Ciencia, Innovación y Universidades

  • PECT DE REUS I EL CAMP DE TARRAGONA PER A UNA ALIMENTACIÓ INNOVADORA, SEGURA, SALUDABLE I SOSTENIBLE PER AL BENESTAR DE LA POBLACIÓ I L’IMPULS DEL TERRITORI (NUTRISALT)
    Cinta Bladé, Begoña Muguerza
    Duració 2017 – 2019
    Generalitat de Catalunya

  • PROYECTO PLATAFORMA PARA LA OBTENCIÓN DE HIDROLIZADOS RICOS EN PÉPTIDOS BIOACTIVOS (PEP)
    2017R2B-04
    Francisca I. Bravo
    Duració 2018 – 2019
    Universitat Rovira i Virgili

  • MULTI‐INGREDIENT FUNCIONAL PER AL TRACTAMENT DE L’OBESITAT (REDOBES)
    2017R2B‐05
    Gerard Aragonès
    Duració 2018-2019
    Universitat Rovira i Virgili

Investigador: María Begoña Muguerza Marquínez (id: 109954), Anna Arola Arnal (id: 110125), Luis Maria Arola Ferrer (id: 110126), Francisca Isabel Bravo Vázquez (id: 110160), Fabiola Consuelo García Reyes (id: 110262), Saioa Gómez Roncal (id: 110278), Néstor Ibarz Blanch (id: 110312), Miguel Mulero Abellán (id: 110404), Gerard Aragonès Bargalló (id: 110612), Jorge Ricardo Soliz Rueda (id: 110532), Manuel Suárez Recio (id: 110534), Cristina Torres Fuentes (id: 110544), Enrique Calvo Manso (id: 111289), Alba García Aranda (id: 111703), Aina Gironès i Garreta (id: 111704), Rafael Ángel López Villalba (id: 111705), Maria Zamora Úbeda (id: 111706), Josep Maria del Bas Prior (id: 111700), Julieta Cirasino Medrano (id: 111701), Cristina Comas Micolau (id: 111702), Antonio Jesús Cortés Espinar (id: 110197), Diego Alavarsa Cascales (id: 112038), Fernando Aniento Marcote (id: 112039), Iván Escobar Martínez (id: 110224), Ignasi Mora Menéndez (id: 112040), Marc Alemany Fornés (id: 110114), María García Martínez (id: 112041)

Técnico: Oksana Harazha (id: 112042)

  • COMPOSICIÓN HIPOLEPTINÉMICA Y SU USO
    F.I. Bravo, M. Suárez, A. Arola-Arnal, B. Muguerza, M.J. Salvadó, L. Arola, A. Crescenti, A. Pascual-Serrano, M. Ibars, A. Ardid-Ruiz, A. Gibert, A. Mas-Capdevila, M. Martín-González, C. Bladé, G. Aragonès.
    P201930732- PCT/ES2020/070483
    Espanya
    Data de prioritat 06/08/2019
    Universitat Rovira i Virgili (URV)

  • HIDROLIZADOS DE GARRAS DE PATAS DE POLLO, SUS PÉPTIDOS Y USOS DE LOS MISMOS
    F. I. Bravo, M. Pinent, A. Casanova-Martí, A. Ardèvol, J. Serrano, L. Arola, B. Muguerza
    ES2702617 B2
    Espanya
    Data de prioritat 04/09/2017
    Universitat Rovira i Virgili (URV)

  • ÁCIDO GÁLICO PARA EL TRATAMIENTO DE PATOLOGÍAS DE LA HIPERACTIVACIÓN DEL SISTEMA RENINA ANGIOTENSINA ALDOSTERONA (SRAA)
    Z. Pons, M. Margalef, F. I. Bravo, A. Arola-Arnal, M. Suárez, L. Arola, B. Muguerza
    P201531587 – ES2611667B1
    Espanya
    Data de prioritat 08/02/2018
    Universitat Rovira i Virgili (URV)

  • PROCEDIMIENTOS PARA LA OBTENCIÓN DE UN HIDROLIZADO DE GARRAS DE PATA DE POLLO CON ACTIVIDAD ANTIHIPERTENSIVA, HIDROLIZADO OBTENIDO Y PÉPTIDOS QUE CONTIENE
    F.I. Bravo, L. Arola, B. Muguerza
    P201531372 PCT/EP2016/072326 (WO2017/050775) ES2606954B1
    Espanya
    Data de prioritat 11/12/2017
    Universitat Rovira i Virgili (URV) – EURECAT

    Sex- and photoperiod-dependent differences in the bioavailability of (poly)phenols from mixtures of seasonal fruit extracts in obese rats.

    Gómez-Roncal S, Ávila-Gálvez MÁ, Alemany-Fornés M, Soliz-Rueda JR, Muguerza B, Espín JC, Arola-Arnal A. 01/07/2026. Food Research International. 235. PMID: 42083179. doi: 10.1016/j.foodres.2026.119110

    Adiponectin modulates the diurnal hepatic transcriptome and energy metabolism in male mice.

    Hirose M, Calvo E, Pilorz V, Kaehler M, Cascorbi I, Nagel I, de Assis LVM, Oster H. 24/04/2026. Endocrine Connections. 15. PMID: 41983416. doi: 10.1530/EC-26-0016

    Significant Activity of Pytren-2Q, a 2-Quinoline Polyamine Compound, against High-Concern Human Pathogenic Fungi.

    Inclán M, Clares MP, Álvarez-Duarte E, Fernández-Silva F, Salas V, Guarro J, Chicote JU, Verdejo B, Delgado-Pinar E, García-España E, García-España A, Calvo E. 17/02/2026. ACS Omega. 11. PMID: 41726695. doi: 10.1021/acsomega.5c09700

    Caffeic acid-functionalized silver nanoparticles for skin therapy: Antioxidant, antibacterial, and anti-melanogenic properties

    Bouaouz, S, Lozano, R, Bravo, FI, Muguerza, B, Mulero, M, Calvo, E, Ortega, P, de la Mata, J. 01/02/2026. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. 116. doi: 10.1016/j.jddst.2025.107937

    Chrononutritional Effects of Cherry Consumption on Hepatic Lipid Profile.

    Ruiz de Azua MJ, Manocchio F, Cruz-Carrión Á, Arola-Arnal A, Gerstner C, Bernal C, Suárez M. 21/01/2026. Nutrients. 18. PMID: 41599958. doi: 10.3390/nu18020345

    S2CIE: semantic, syntactic, and context-based information extraction for AOP development

    Kumar, S, Sharma, S, Deepika, D, Biosca-Brull, J, Moreno, A, Kumar, V. 01/01/2026. Environment International. 207. PMID: 41386052. doi: 10.1016/j.envint.2025.109986

    Impact of Intended Isocaloric Early versus Late Time-Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial.

    Szekely K, Gerl MJ, Peters B, Schwarz J, Schuppelius B, Damm M, Soliz-Rueda JR, Sehgal R, Lazaratos M, Klose C, Simons K, Pfeiffer AFH, Schürmann A, Kramer A, Michalsen A, Pivovarova-Ramich O. 01/01/2026. Advanced Science. 13. PMID: 41186047. doi: 10.1002/advs.202507149

    Neuroprotective effects of polyphenol-rich extracts obtained from agricultural by-products in an induced cognitive decline model of zebrafish larvae and in human neurons.

    Castillo-Moral Á, Tchoumtchoua J, Leonard K, Del Bas JM, Ortega N, Escoté X, Teichenné J. 01/12/2025. Biomedicine & Pharmacotherapy. 193. PMID: 41232357. doi: 10.1016/j.biopha.2025.118776

    Interaction Between Photoperiod and Sex on Hepatic Lipid Homeostasis in Rats Fed an Obesogenic Diet

    Gomez-Roncal, S, García-Reyes, FC, Soliz-Rueda, JR, Calvo, E, Suárez, M, Muguerza, B, Arola-Arnal, A. 27/11/2025. Faseb Journal. 39. PMID: 41307196. doi: 10.1096/fj.202503210R

    Grape Seed Flavanols Restore Peripheral Clock of White Adipose Tissue in Obese Rats Under Circadian Alterations

    García-Martínez-Salvador, M, Colom-Pellicer, M, Podolakova, E, Mulero, M, Aragonès, G, Soliz-Rueda, JR, Muguerza, B. 14/11/2025. Nutrients. 17. PMID: 41305614. doi: 10.3390/nu17223564

    Microbial Biotransformation of Agro-Industrial Fibre-Rich By-Products into Functional Beverages.

    Sentís-Moré P, Robles-Rodríguez I, Leonard K, Tchoumtchoua J, Escoté-Miró X, Del Bas-Prior JM, Ortega-Olivé N. 05/11/2025. Antioxidants. 14. PMID: 41300489. doi: 10.3390/antiox14111332

    Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats

    Gómez-Roncal, S, Gironès-Garreta, A, Suárez, M, Muguerza, B, Aragonès, G, Mulero, M, Arola-Arnal, A. 01/11/2025. Journal Of Physiology And Biochemistry. 81. PMID: 40493338. doi: 10.1007/s13105-025-01075-w

    A Combination of Lacticaseibacillus paracasei CECT 30660 and Bifidobacterium longum subsp. infantis CECT 7210 Cell-Free Supernatants Reduces LPS-Induced Preterm Birth and Systemic Inflammation in Pregnant Mice

    Quesada-Vázquez, S, García, MCD, Cifuentes-Orjuela, G, Antolín, A, Alcaide-Hidalgo, JM, Jiménez, J, Puiggròs, F, Caimari, A, Sabench, F, Del Bas, JM, Escoté, X, Moreno-Muñoz, JA. 31/10/2025. Nutrients. 17. PMID: 41228502. doi: 10.3390/nu17213429

    Circannual Rhythms Affect the Bioavailability of Phenolic Compounds from Grape Seed Proanthocyanidins Extract Differently in Healthy and Obese Fischer 344 Rats

    Escobar-Martinez, I, Arreaza-Gil, V, Arola-Arnal, A, Muguerza, B, Mulero, M, Suarez, M, Torres-Fuentes, C. 08/10/2025. Journal Of Agricultural And Food Chemistry. 73. PMID: 41002217. doi: 10.1021/acs.jafc.5c03952

    Diamine oxidase deficiency implications for health, current management, and future directions in the treatment of histamine intolerance: A review.

    Alemany-Fornés M, Bori J, Muguerza B, Suárez M. 01/10/2025. International Journal Of Biological Macromolecules. 327. PMID: 40865824. doi: 10.1016/j.ijbiomac.2025.147130

    Impact of the natural female reproductive aging on the rat serum lipidome.

    Baudin J, Antolín A, Fernández-Arroyo S, Del Pino A, Mulero F, Puiggròs F, Arola L, Caimari A. 18/09/2025. Clinical Science. 139. PMID: 40891175. doi: 10.1042/CS20255841

    Interplay between (poly)phenols, gut microbiota, and biological rhythms: outlook for a new paradigm in brain health

    Torres-Fuentes, C, Schellekens, H, Cryan, JF, Espin, JC, Muguerza, B. 10/09/2025. Critical Reviews In Food Science And Nutrition. 66. PMID: 40944699. doi: 10.1080/10408398.2025.2559367

    Impact of a high-fat diet on spatial learning and memory: The role of sex, APOE genotype, and postnatal chlorpyrifos exposure

    Guardia-Escote, L, Biosca-Brull, J, Blanco, J, Cabré, M, Basaure, P, Pérez-Fernández, C, Sánchez-Santed, F, Domingo, JL, Colomina, MT. 01/09/2025. Neurotoxicology. 110. PMID: 40653054. doi: 10.1016/j.neuro.2025.07.004

    Photoperiod-Dependent Effects of Phenolic-Enriched Fruit Extracts on Postprandial Triacylglyceride Levels and Acute Inflammatory Responses in F344 Rats

    Manocchio, F, Morales, D, Navarro-Masip, E, Aragones, G, Torres-Fuentes, C, Bravo, FI, Muguerza, B. 01/08/2025. Molecular Nutrition & Food Research. 69. PMID: 40411868. doi: 10.1002/mnfr.70126

    Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet-Induced Obese Rats.

    Ibars-Serra M, Pascual-Serrano A, Ardid-Ruiz A, Doladé N, Aguilar-González S, Cirasino J, Muguerza B, Suárez M, Keijer J, Arola-Arnal A, Aragonès G. 01/08/2025. Molecular Nutrition & Food Research. 69. PMID: 40289401. doi: 10.1002/mnfr.70075

    Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity.

    Fernández-Rhodes M, Suárez M, Molet I, Suárez-García S, Arola L, Sze SK, Gallart-Palau X, Serra A. 10/06/2025. ACS Omega. 10. PMID: 40521556. doi: 10.1021/acsomega.5c02274

    Grape seed procyanidins modulate PER2 circadian rhythm and lipid metabolism of white adipose tissue explants in a time-dependent manner

    Colom-Pellicer, M, de Assis, LVM, Rodríguez, RM, Suaárez, M, Mulero, M, Arola-Arnal, A, Oster, H, Aragonès, G, Calvo, E. 19/05/2025. International Journal Of Food Sciences And Nutrition. 76. PMID: 40300822. doi: 10.1080/09637486.2025.2494151

    Foodomics approaches: New insights in phenolic compounds analysis

    Gómez-Rocal, S, Cruz-Carrión, A, Morales, D, García-Ruiz, A, Suárez, M, Arola-Arnal, A. 01/05/2025. Food Research International. 208. PMID: 40263832. doi: 10.1016/j.foodres.2025.116168

    Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols

    Soliz-Rueda, JR, López-Fernández-Sobrino, R, Schellekens, H, Bravo, FI, Suárez, M, Mulero, M, Muguerza, B. 20/01/2025. Biofactors. 51. PMID: 39832727. doi: 10.1002/biof.70000

    Gut microbiota and eating behaviour in circadian syndrome.

    Soliz-Rueda JR, Cuesta-Marti C, O’Mahony SM, Clarke G, Schellekens H, Muguerza B. 01/01/2025. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 36. PMID: 39095231. doi: 10.1016/j.tem.2024.07.008

    Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics.

    Ramos-Lopez O, Assmann TS, Astudillo Muñoz EY, Baquerizo-Sedano L, Barrón-Cabrera E, Bernal CA, Bressan J, Cuevas-Sierra A, Dávalos A, De la Cruz-Mosso U, De la Garza AL, De Luis DA, Díaz de la Garza RI, Dos Santos K, Fernández-Condori RC, Fernández-Quintela A, Garcia Diaz DF, Gonzalez-Becerra K, Lopes Rosado E, López de Las Hazas MC, Marín Alejandre BA, Angel Martin A, Martinez-Lopez E, Martínez-Urbistondo D, Milagro FI, Hermsdorff HHM, Muguerza B, Nicoletti CF, Obregón Rivas AM, Parra-Rojas I, Portillo MP, Santos JL, Steemburgo T, Tejero ME, Terán AC, Treviño V, Vizmanos B, Martinez JA. 01/01/2025. Lifestyle Genomics. 18. PMID: 39617000. doi: 10.1159/000542789

    Grape-Seed Proanthocyanidin Extract (GSPE) Modulates Diurnal Rhythms of Hepatic Metabolic Genes and Metabolites, and Reduces Lipid Deposition in Cafeteria-Fed Rats in a Time-of-Day-Dependent Manner

    Rodríguez, RM, de Assis, LVM, Calvo, E, Colom-Pellicer, M, Quesada-Vázquez, S, Cruz-Carrión, A, Escoté, X, Oster, H, Aragonès, G, Mulero, M. 01/12/2024. Molecular Nutrition & Food Research. 68. PMID: 39523911. doi: 10.1002/mnfr.202400554

    Sweet cherries modulate thyroid hormones and hepatic glucose metabolism in F344 rats in a photoperiod-dependent manner

    Manocchio, F, de Azua, MJR, Navarro-Masip, E, Morales, D, Aragonès, G, Torres-Fuentes, C, Muguerza, B, Bravo, FI. 01/10/2024. Journal Of Functional Foods. 121. doi: 10.1016/j.jff.2024.106415

    A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats

    Baudin, J, Hernandez-Baixauli, J, Romero-Giménez, J, Yang, H, Mulero, F, Puiggròs, F, Mardinoglu, A, Arola, L, Caimari, A. 01/10/2024. Biomedicine & Pharmacotherapy. 179. PMID: 39208671. doi: 10.1016/j.biopha.2024.117326

    Photoperiod effects on corticosterone and seasonal clocks in cafeteria-induced obese fischer 344 rats are influenced by gut microbiota

    Arreaza-Gil, V, Escobar-Martínez, I, Soliz-Rueda, JR, Suárez, M, Muguerza, B, Schellekens, H, Torres-Fuentes, C, Arola-Arnal, A. 29/09/2024. Scientific Reports. 14. PMID: 39343766. doi: 10.1038/s41598-024-73289-9

    Time-of-Day Adrenal Modulation of Corticosterone Synthesis is Affected by Sex and Diet but Not by Proanthocyanidins in Rat

    Romero, MD, Martín-González, MZ, Aragonès, G, Muguerza, B, Remesar, X, Arola-Arnal, A, Fernández-López, JA. 01/09/2024. Molecular Nutrition & Food Research. 68. PMID: 39148153. doi: 10.1002/mnfr.202400323

    Sex Differences in the Absorption, Disposition, Metabolism, and Excretion of Grape Seed Proanthocyanidins in Prepubescent Rats

    Iglesias-Carres, L, Mas-Capdevila, A, Bravo, FI, Suárez, M, Arola-Arnal, A, Muguerza, B. 01/09/2024. Molecular Nutrition & Food Research. 68. PMID: 39194387. doi: 10.1002/mnfr.202400399

    Photoperiod-Dependent Effects on Blood Biochemical Markers of Phenolic-Enriched Fruit Extracts

    Manocchio, F, Morales, D, Navarro-Masip, E, Aragonès, G, Torres-Fuentes, C, Bravo, FI, Muguerza, B. 29/05/2024. Journal Of Agricultural And Food Chemistry. 72. PMID: 38811015. doi: 10.1021/acs.jafc.4c01698

    Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats

    Baudin, J, Hernandez-Baixauli, J, Quesada-Vázquez, S, Mulero, F, Puiggròs, F, Arola, L, Caimari, A. 07/05/2024. Food & Function. 15. PMID: 38598180. doi: 10.1039/d3fo05122f

    Usefulness of Opuntia spp. on the Management of Obesity and Its Metabolic Co-Morbidities

    Gómez-García, I, Fernández-Quintela, A, González, M, Gómez-Zorita, S, Muguerza, B, Trepiana, J, Portillo, MP. 01/05/2024. Nutrients. 16. PMID: 38732528. doi: 10.3390/nu16091282

    Valorization of Peach Fruit and Wine Lees through the Production of a Functional Peach and Grape Juice

    Prieto-Santiago, V, Aguiló-Aguayo, I, Bravo, FI, Mulero, M, Abadias, M. 01/04/2024. Foods. 13. PMID: 38611399. doi: 10.3390/foods13071095

    Cherries with Different Geographical Origins Regulate Neuroprotection in a Photoperiod-Dependent Manner in F344 Rats

    Manocchio, F, Bravo, FI, Helfer, G, Muguerza, B. 01/01/2024. Antioxidants. 13. PMID: 38247496. doi: 10.3390/antiox13010072

    Exploring Metabolic and Gut Microbiome Responses to Paraquat Administration in Male Wistar Rats: Implications for Oxidative Stress

    Hernandez-Baixauli, J, Chomiciute, G, Tracey, H, Mora, I, Cortés-Espinar, AJ, Avila-Román, J, Abasolo, N, Palacios-Jordan, H, Foguet-Romero, E, Suñol, D, Galofré, M, Alcaide-Hidalgo, JM, Baselga-Escudero, L, del Bas, JM, Mulero, M. 01/01/2024. Antioxidants. 13. PMID: 38247491. doi: 10.3390/antiox13010067

    Abrupt Photoperiod Changes Differentially Modulate Hepatic Antioxidant Response in Healthy and Obese Rats: Effects of Grape Seed Proanthocyanidin Extract (GSPE)

    Cortés-Espinar, AJ, Ibarz-Blanch, N, Soliz-Rueda, JR, Calvo, E, Bravo, FI, Mulero, M, Avila-Román, J. 01/12/2023. International Journal Of Molecular Sciences. 24. PMID: 38069379. doi: 10.3390/ijms242317057

    Novel kombucha beverages with antioxidant activity based on fruits as alternative substrates

    Morales, D, Gutiérez-Pensado, R, Bravo, FI, Muguerza, B. 01/11/2023. Lwt-Food Science And Technology. 189. doi: 10.1016/j.lwt.2023.115482

    Photoperiod-Dependent Effects of Grape-Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats

    Navarro-Masip, Elia, Manocchio, Francesca, Rodriguez, Romina M. M., Bravo, Francisca Isabel, Torres-Fuentes, Cristina, Muguerza, Begona, Aragones, Gerard. 01/09/2023. Molecular Nutrition & Food Research. 67. PMID: 37423963. doi: 10.1002/mnfr.202300035

    Chicken slaughterhouse by-products: A source of protein hydrolysates to manage non-communicable diseases

    Ibarz-Blanch, N, Alcaide-Hidalgo, JM, Cortés-Espinar, AJ, Albi-Puig, J, Suárez, M, Mulero, M, Morales, D, Bravo, FI. 01/09/2023. Trends In Food Science & Technology. 139. doi: 10.1016/j.tifs.2023.104125

    Vitis vinifera L. Bioactive Components Modulate Adipose Tissue Metabolic Markers of Healthy Rats in a Photoperiod-Dependent Manner.

    Navarro-Masip È, Manocchio F, Colom-Pellicer M, Escoté X, Iglesias-Carres L, Calvo E, Bravo FI, Muguerza B, Desjardins Y, Aragonès G. 01/09/2023. Molecular Nutrition & Food Research. 67. PMID: 37421210. doi: 10.1002/mnfr.202300074

    Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats

    Cortés-Espinar, AJ, Ibarz-Blanch, N, Soliz-Rueda, JR, Bonafos, B, Feillet-Coudray, C, Casas, F, Bravo, FI, Calvo, E, Avila-Román, J, Mulero, M. 01/08/2023. Antioxidants. 12. PMID: 37627601. doi: 10.3390/antiox12081606

    Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD

    Marsal-Beltran, A, Rodríguez-Castellano, A, Astiarraga, B, Calvo, E, Rada, P, Madeira, A, Rodríguez-Peña, MM, Llauradó, G, Núñez-Roa, C, Gómez-Santos, B, Maymó-Masip, E, Bosch, R, Frutos, MD, Moreno-Navarrete, JM, Ramos-Molina, B, Aspichueta, P, Joven, J, Fernández-Real, JM, Quera, JC, Valverde, AM, Pardo, A, Vendrell, J, Ceperuelo-Mallafré, V, Fernández-Veledo, S. 01/08/2023. Metabolism-Clinical And Experimental. 145. PMID: 37315889. doi: 10.1016/j.metabol.2023.155630

    Metabolism disturbance by light/dark cycle switching depends on the rat health status: the role of grape seed flavanols

    Soliz-Rueda, JR, López-Fernández-Sobrino, R, Torres-Fuentes, C, Bravo, FI, Suárez, M, Mulero, M, Muguerza, B. 17/07/2023. Food & Function. 14. PMID: 37377055. doi: 10.1039/d3fo00260h

    Fucosylated N-glycans as early biomarkers of COVID-19 severity

    Paton, B, Herrero, P, Peraire, J, del Pino, A, Chafino, S, Martinez-Picado, J, Gómez-Bertomeu, F, Rull, A, Canela, N, Suárez, M. 05/06/2023. Frontiers in immunology. 14. PMID: 37342334. doi: 10.3389/fimmu.2023.1204661

    Gut Microbiota Influences the Photoperiod Effects on Proanthocyanidins Bioavailability in Diet-Induced Obese Rats

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    Blood Pressure-Lowering Effect of Wine Lees: Dose-Response Study, Effect of Dealcoholization and Possible Mechanisms of Action

    López-Fernández-Sobrino, R, Soliz-Rueda, JR, Suárez, M, Mulero, M, Arola, L, Bravo, FI, Muguerza, B. 01/04/2021. Nutrients. 13. PMID: 33808475. doi: 10.3390/nu13041142

    ACE Inhibitory and Antihypertensive Activities of Wine Lees and Relationship among Bioactivity and Phenolic Profile

    López-Fernández-Sobrino, R, Soliz-Rueda, JR, Margalef, M, Arola-Arnal, A, Suárez, M, Bravo, FI, Muguerza, B. 01/02/2021. Nutrients. 13. PMID: 33672674. doi: 10.3390/nu13020679

    Enzyme-Assisted Extraction to Obtain Phenolic-Enriched Wine Lees with Enhanced Bioactivity in Hypertensive Rats

    López-Fernández-Sobrino, R, Margalef, M, Torres-Fuentes, C, Avila-Román, J, Aragonès, G, Muguerza, B, Bravo, FI. 01/04/2021. Antioxidants. 10. PMID: 33810336. doi: 10.3390/antiox10040517

    A multifunctional ingredient for the management of metabolic syndrome in cafeteria diet-fed rats

    Martín-González, MZ, Palacios-Jordan, H, Mas-Capdevila, A, Rodríguez, MA, Bravo, FI, Muguerza, B, Aragonès, G. 21/01/2021. Food & Function. 12. PMID: 33399141. doi: 10.1039/d0fo02810j

    A novel dietary multifunctional ingredient reduces body weight and improves leptin sensitivity in cafeteria diet-fed rats

    Martín-González, MZ, Palacios-Jordan, H, Ibars, M, Ardid-Ruiz, A, Gibert-Ramos, A, Rodríguez, MA, Suárez, M, Muguerza, B, Aragonès, G. 01/10/2020. Journal Of Functional Foods. 73. doi: 10.1016/j.jff.2020.104141

    Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease

    Ruskovska, T, Massaro, M, Carluccio, MA, Arola-Arnal, A, Muguerza, B, Vanden Berghe, W, Declerk, K, Bravo, FI, Calabriso, N, Combet, E, Gibney, ER, Gomes, A, Gonthier, MP, Kistanova, E, Krga, I, Mena, P, Morand, C, dos Santos, CN, De Pascual-Teresa, S, Rodriguez-Mateos, A, Scoditti, E, Suárez, M, Milenkovic, D. 01/06/2020. Food & Function. 11. PMID: 32537624. doi: 10.1039/d0fo00701c

    Virgin olive oil (unfiltered) extract contains peptides and possesses ACE inhibitory and antihypertensive activity

    Alcaide-Hidalgo, JM, Margalef, M, Bravo, FI, Muguerza, B, López-Huertas, E. 01/04/2020. Clinical Nutrition. 39. PMID: 31178246. doi: 10.1016/j.clnu.2019.05.016

    The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats

    Palacios-Jordan, H, Martín-González, MZ, Suárez, M, Aragonès, G, Muguerza, B, Rodríguez, MA, Bladé, C. 01/04/2020. Nutrients. 12. PMID: 32295282. doi: 10.3390/nu12041085

    Response to: Comment About Statistical Analysis of a Cluster-Randomized Trial About Clustering and Nesting (DOI: 10.1089/chi.2019.0142)

    Aceves-Martins, M, Llauradó, E, Tarro, L, Moriña, D, Papell-Garcia, I, Prades-Tena, J, Kettner-Hoeberg, H, Puiggròs, F, Arola, L, Davies, A, Giralt, M, Solà, R. 01/03/2020. Childhood Obesity. 16. PMID: 32078371. doi: 10.1089/chi.2019.0265

    Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

    Martín-González, MZ, Palacios, H, Rodríguez, MA, Arola, L, Aragonès, G, Muguerza, B. 01/02/2020. Nutrients. 12. PMID: 32033223. doi: 10.3390/nu12020408

    Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension

    Mas-Capdevila, A, Iglesias-Carres, L, Arola-Arnal, A, Suárez, M, Bravo, FI, Muguerza, B. 01/10/2020. Food & Function. 11. PMID: 32945822. doi: 10.1039/d0fo00981d

    Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide

    Mas-Capdevila, A, Iglesias-Carres, L, Arola-Arnal, A, Aragonès, G, Muguerza, B, Bravo, FI. 01/07/2020. Biomolecules. 10. PMID: 32630658. doi: 10.3390/biom10070992

    Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

    Pla-Pagà, L, Guirro, M, Gual-Grau, A, Gibert-Ramos, A, Foguet-Romero, E, Catalan, U, Mayneris-Perxachs, J, Canela, N, Valls, RM, Arola, L, Solà, R, Pedret, A. 01/05/2020. Molecular Nutrition & Food Research. 64. PMID: 32281714. doi: 10.1002/mnfr.201901063

    Obesogenic effects of chlorpyrifos and its metabolites during the differentiation of 3T3-L1 preadipocytes

    Blanco, J, Guardia-Escote, L, Mulero, M, Basaure, P, Biosca-Brull, J, Cabré, M, Colomina, MT, Domingo, JL, Sánchez, DJ. 01/03/2020. Food And Chemical Toxicology. 137. PMID: 32017950. doi: 10.1016/j.fct.2020.111171

    Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells

    Ardid-Ruiz, A, Ibars, M, Mena, P, Del Rio, D, Muguerza, B, Arola, L, Aragonès, G, Suárez, M. 01/12/2019. International Journal Of Molecular Sciences. 20. PMID: 31842467. doi: 10.3390/ijms20246282

    A comparative study on the bioavailability of phenolic compounds from organic and nonorganic red grapes

    Iglesias-Carres, L, Mas-Capdevila, A, Bravo, FI, Aragonès, G, Arola-Arnal, A, Muguerza, B. 30/11/2019. Food Chemistry. 299. PMID: 31280001. doi: 10.1016/j.foodchem.2019.125092

    Optimization and characterization of Royal Dawn cherry (Prunus avium) phenolics extraction

    Iglesias-Carres, L, Mas-Capdevila, A, Bravo, FI, Mulero, M, Muguerza, B, Arola-Arnal, A. 26/11/2019. Scientific Reports. 9. PMID: 31772244. doi: 10.1038/s41598-019-54134-w

    Chrononutrition and Polyphenols: Roles and Diseases

    Arola-Arnal, A, Cruz-Carrión, A, Torres-Fuentes, C, Avila-Román, J, Aragonès, G, Mulero, M, Bravo, FI, Muguerza, B, Arola, L, Suárez, M. 01/11/2019. Nutrients. 11. PMID: 31671606. doi: 10.3390/nu11112602

    Optimization of extraction methods for characterization of phenolic compounds in apricot fruit (Prunus armeniaca)

    Iglesias-Carres, L, Mas-Capdevila, A, Bravo, FI, Bladé, C, Arola-Arnal, A, Muguerza, B. 01/10/2019. Food & Function. 10. PMID: 31535681. doi: 10.1039/c9fo00353c

    Exposure of Fischer 344 rats to distinct photoperiods influences the bioavailability of red grape polyphenols

    Iglesias-Carres, L, Mas-Capdevila, A, Bravo, FI, Arola, L, Muguerza, B, Arola-Arnal, A. 01/10/2019. Journal Of Photochemistry And Photobiology B-Biology. 199. PMID: 31525717. doi: 10.1016/j.jphotobiol.2019.111623

    Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial

    Pedret, A, Valls, RM, Calderón-Pérez, L, Llauradó, E, Companys, J, Pla-Pagà, L, Moragas, A, Martín-Luján, F, Ortega, Y, Giralt, M, Caimari, A, Chenoll, E, Genovés, S, Martore, P, Codoñer, FM, Ramón, D, Arola, L, Solà, R. 01/09/2019. International Journal Of Obesity. 43. PMID: 30262813. doi: 10.1038/s41366-018-0220-0

    Antihyperglycemic effect of a chicken feet hydrolysate via the incretin system: DPP-IV-inhibitory activity and GLP-1 release stimulation

    Casanova-Martí, A, Bravo, FI, Serrano, J, Ardévol, A, Pinent, M, Muguerza, B. 01/07/2019. Food & Function. 10. PMID: 31225553. doi: 10.1039/c9fo00695h

    Novel Antihypertensive Peptides Derived from Chicken Foot Proteins

    Bravo, FI, Mas-Capdevila, A, Margalef, M, Arola-Arnal, A, Muguerza, B. 01/06/2019. Molecular Nutrition & Food Research. 63. PMID: 30924597. doi: 10.1002/mnfr.201801176

    Impact of a youth-led social marketing intervention run by adolescents to encourage healthy lifestyles among younger school peers (EYTO-Kids project): a parallel-cluster randomised controlled pilot study

    Tarro, L, Llauradó, E, Aceves-Martins, M, Moriña, D, Papell-Garcia, I, Arola, L, Giralt, M, Solà, R. 01/04/2019. Journal Of Epidemiology And Community Health. 73. PMID: 30683803. doi: 10.1136/jech-2017-210163

    Long-term administration of protein hydrolysate from chicken feet induces antihypertensive effect and confers vasoprotective pattern in diet-induced hypertensive rats

    Mas-Capdevila, A, Iglesias-Carres, L, Arola-Arnal, A, Suarez, M, Muguerza, B, Bravo, FI. 01/04/2019. Journal Of Functional Foods. 55. doi: 10.1016/j.jff.2019.02.006

    Potential Use of Mobile Phone Applications for Self-Monitoring and Increasing Daily Fruit and Vegetable Consumption: A Systematized Review

    Mandracchia, F, Llauradó, E, Tarro, L, del Bas, JM, Valls, RM, Pedret, A, Radeva, P, Arola, L, Solà, R, Boqué, N. 22/03/2019. Nutrients. 11. PMID: 30909484. doi: 10.3390/nu11030686

    Evidence that Nitric Oxide is Involved in the Blood Pressure Lowering Effect of the Peptide AVFQHNCQE in Spontaneously Hypertensive Rats

    Mas-Capdevila, A, Iglesias-Carres, L, Arola-Arnal, A, Aragonès, G, Aleixandre, A, Bravo, FI, Muguerza, B. 01/02/2019. Nutrients. 11. PMID: 30678184. doi: 10.3390/nu11020225

    Optimization of a polyphenol extraction method for sweet orange pulp (Citrus sinensis L.) to identify phenolic compounds consumed from sweet oranges

    Iglesias-Carres, L, Mas-Capdevila, A, Bravo, FI, Aragonès, G, Muguerza, B, Arola-Arnal, A. 30/01/2019. Plos One. 14. PMID: 30699169. doi: 10.1371/journal.pone.0211267

    Criteria for referring patients to Spanish Atherosclerosis Society lipid units

    Sánchez-Chaparro, MA, Pérez-Martínez, P, Ibarretxe, D, Suárez-Tembra, M, Valdivielso, P, Ros, E, Martínez, S, Cenarro, A, Sánchez, MA, Ibarretxe, D, Suárez, M, Muñiz, O, Pérez, P, Blanco, A, Vea, A, Toro, R, Serra, E, Romero, MJ, Rodriguez, C, Pardo, A, Márquez, L, de los Santos, A, Corrales, MA, Caixàs, A, Bueno, M. 01/01/2019. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 31. PMID: 30257791. doi: 10.1016/j.arteri.2018.04.005

    Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation

    Ardid-Ruiz, A, Ibars, M, Mena, P, Del Rio, D, Muguerza, B, Bladé, C, Arola, L, Aragonès, G, Suárez, M. 01/11/2018. Nutrients. 10. PMID: 30441779. doi: 10.3390/nu10111757

    Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde.

    Tomas-Hernandez S, Garcia-Vallvé S, Pujadas G, Valls C, Ojeda-Montes MJ, Gimeno A, Cereto-Massagué A, Roca-Martinez J, Suárez M, Arola L, Blanco J, Mulero M, Beltran-Debón R. 24/10/2018. Journal Of Agricultural And Food Chemistry. 66. PMID: 30269491. doi: 10.1021/acs.jafc.8b00782

    MicroRNAs Clustered within the 14q32 Locus Are Associated with Endothelial Damage and Microparticle Secretion in Bicuspid Aortic Valve Disease

    Martínez-Micaelo, N, Beltrán-Debón, R, Aragonés, G, Faiges, M, Alegret, JM. 05/09/2017. Frontiers in Physiology. 8. PMID: 28928672. doi: 10.3389/fphys.2017.00648

    CANDIDATES FOR MONOCLONAL ANTIBODIES TO PCSK9, AMONG HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA PATIENTS IN THE DYSLIPIDEMIA REGISTRY OF THE SPANISH ATHEROSCLEROSIS SOCIETY

    Perez-Calahorra, S, Plana, N, Sanchez-Hernandez, RM, Marco-Benedi, V, Brea, A, Suarez, M, Mauri, M, Villa, A, Martorell, E, Lahoz, C. 01/08/2017. Atherosclerosis. 263. doi: 10.1016/j.atherosclerosis.2017.06.147

    Data on the circulating levels of endothelial microparticles are elevated in patients with bicuspid aortic valve and are related to aortic dilation.

    Alegret JM, Martínez-Micaelo N, Aragonès G, Beltrán-Debón R. 01/09/2016. Data in brief. 8. PMID: 27453924. doi: 10.1016/j.dib.2016.06.026

    Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation

    Alegret, JM, Martínez-Micaelo, N, Aragonès, G, Beltrán-Debón, R. 15/08/2016. International Journal Of Cardiology. 217. PMID: 27179206. doi: 10.1016/j.ijcard.2016.04.184

    Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats

    Aragonès, G, Suárez, M, Ardid-Ruiz, A, Vinaixa, M, Rodríguez, MA, Correig, X, Arola, L, Bladé, C. 22/04/2016. Scientific Reports. 6. PMID: 27102823. doi: 10.1038/srep24977

    Impact of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on the HDL Proteome in Hypercholesterolemic Subjects: A Double Blind, Randomized, Controlled, Cross-Over Clinical Trial (VOHF Study)

    Pedret, A, Catalán, U, Fernández-Castillejo, S, Farràs, M, Valls, RM, Rubió, L, Canela, N, Aragonés, G, Romeu, M, Castañer, O, de la Torre, R, Covas, MI, Fitó, M, Motilva, MJ, Solà, R. 10/06/2015. Plos One. 10. PMID: 26061039. doi: 10.1371/journal.pone.0129160

    Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A randomised controlled trial

    Valls, RM, Farràs, M, Suárez, M, Fernández-Castillejo, S, Fitó, M, Konstantinidou, V, Fuentes, F, López-Miranda, J, Giralt, M, Covas, MI, Motilva, MJ, Solà, R. 15/01/2015. Food Chemistry. 167. PMID: 25148955. doi: 10.1016/j.foodchem.2014.06.107

    Association Between rs2200733 and rs7193343 Genetic Variants and Atrial Fibrillation in a Spanish Population, and Meta-analysis of Previous Studies

    Ferrán, A, Alegret, JM, Subirana, I, Aragonés, G, Lluis-Ganella, C, Romero-Menor, C, Planas, F, Joven, J, Elosua, R. 01/10/2014. REVISTA ESPANOLA DE CARDIOLOGIA. 67. PMID: 25262128. doi: 10.1016/j.rec.2013.12.019

    Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function

    Joven, J, March, I, Espinel, E, Fernández-Arroyo, S, Rodríguez-Gallego, E, Aragonès, G, Beltrán-Debón, R, Alonso-Villaverde, C, Rios, L, Martin-Paredero, V, Menendez, JA, Micol, V, Segura-Carretero, A, Camps, J. 01/06/2014. Molecular Nutrition & Food Research. 58. PMID: 24668839. doi: 10.1002/mnfr.201300774

    Rosiglitazone and Fenofibrate Exacerbate Liver Steatosis in a Mouse Model of Obesity and Hyperlipidemia. A Transcriptomic and Metabolomic Study

    Rull, A, Geeraert, B, Aragonès, G, Beltrán-Debón, R, Rodríguez-Gallego, E, García-Heredia, A, Pedro-Botet, J, Joven, J, Holvoet, P, Camps, J. 01/03/2014. Journal Of Proteome Research. 13. PMID: 24479691. doi: 10.1021/pr401230s

    The relevance of the association between inflammation and atrial fibrillation

    Alegret, JM, Aragonès, G, Elosua, R, Beltrán-Debón, R, Hernández-Aguilera, A, Romero-Menor, C, Camps, J, Joven, J. 01/04/2013. European Journal Of Clinical Investigation. 43. PMID: 23397981. doi: 10.1111/eci.12047

    THE RELEVANCE OF THE ASSOCIATION BETWEEN INFLAMMATION AND ATRIAL FIBRILLATION

    Alegret, JM, Aragonès, G, Beltrán-Debón, R, Elosua, R, Ligero, C, Valdovinos, P, Romero-Menor, C, Joven, J. 12/03/2013. Journal Of The American College Of Cardiology. 61. doi: 10.1016/S0735-1097(13)60314-9

    Factors Related to the Need for Surgery after the Diagnosis of Bicuspid Aortic Valve: One Center's Experience under a Conservative Approach

    Alegret, JM, Ligero, C, Vernis, JM, Beltrán-Debón, R, Aragonés, G, Duran, I, Palazón, O, Hernandez-Aparicio, A. 01/01/2013. International Journal Of Medical Sciences. 10. PMID: 23329890. doi: 10.7150/ijms.5399

    A possible role for CCR5 in the progression of atherosclerosis in HIV-infected patients: a cross-sectional study

    Fernández-Sender, L, Alonso-Villaverde, C, Rull, A, Rodríguez-Gallego, E, Riera-Borrull, M, Hernández-Aguilera, A, Camps, J, Beltrán-Debón, R, Aragonès, G, Menendez, JA, Joven, J. 09/05/2013. Aids Research And Therapy. 10. PMID: 23659629. doi: 10.1186/1742-6405-10-11

    Metformin: a cheap and well-tolerated drug that provides benefits for viral infections

    Joven, J, Menéndez, JA, Fernandez-Sender, L, Espinel, E, Rull, A, Beltrán-Debón, R, Rodríguez-Gallego, E, Riera-Borrull, M, Pedro-Botet, J, Alonso-Villaverde, C, Camps, J, Aragonès, G. 01/04/2013. Hiv Medicine. 14. PMID: 23171036. doi: 10.1111/hiv.12000

    Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil A new family of gerosuppressant agents

    Menendez, JA, Joven, J, Aragonès, G, Barrajón-Catalán, E, Beltrán-Debón, R, Borrás-Linares, I, Camps, J, Corominas-Faja, B, Cufí, S, Fernández-Arroyo, S, Garcia-Heredia, A, Hernández-Aguilera, A, Herranz-López, M, Jiménez-Sánchez, C, López-Bonet, E, Lozano-Sánchez, J, Luciano-Mateo, F, Martin-Castillo, B, Martin-Paredero, V, Pérez-Sánchez, A, Oliveras-Ferraros, C, Riera-Borrull, M, Rodríguez-Gallego, E, Quirantes-Piné, R, Rull, A, Tomás-Menor, L, Vazquez-Martin, A, Alonso-Villaverde, C, Micol, V, Segura-Carretero, A. 15/02/2013. Cell Cycle. 12. PMID: 23370395. doi: 10.4161/cc.23756

    Ubiquitous Transgenic Overexpression of C-C Chemokine Ligand 2: A Model to Assess the Combined Effect of High Energy Intake and Continuous Low-Grade Inflammation

    Rodríguez-Gallego, E, Riera-Borrull, M, Hernández-Aguilera, A, Mariné-Casadó, R, Rull, A, Beltrán-Debon, R, Luciano-Mateo, F, Menendez, JA, Vazquez-Martin, A, Sirvent, JJ, Martín-Paredero, V, Corbi, AL, Sierra-Filardi, E, Aragonés, G, García-Heredia, A, Camps, J, Alonso-Villaverde, C, Joven, J. 01/01/2013. Mediators Of Inflammation. 2013. PMID: 24453432. doi: 10.1155/2013/953841

    PLANT-DERIVED POLYPHENOLS REGULATE MIRNA PARALOGS MIR-103/107 AND MIR-122 EXPRESSION AND PREVENT DIET-INDUCED FATTY LIVER DISEASE IN HYPERLIPEMIC MICE

    Beltran-Debon, R, Rull, A, Aragonès, G, Rodríguez-Gallego, E, Riera-Borrull, M, Camps, J, Joven, J. 01/04/2012. Journal Of Hepatology. 56. doi: 10.1016/S0168-8278(12)61231-8

    Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease

    Rull, A, García, R, Fernández-Sender, L, García-Heredia, A, Aragonès, G, Beltrán-Debón, R, Marsillach, J, Alegret, JM, Martín-Paredero, V, Mackness, B, Mackness, M, Joven, J, Camps, J. 01/02/2012. Atherosclerosis. 220. PMID: 22153698. doi: 10.1016/j.atherosclerosis.2011.11.021

    Serum paraoxonase-3 concentration in HIV-infected patients. Evidence for a protective role against oxidation

    Aragonès, G, García-Heredia, A, Guardiola, M, Rull, A, Beltrán-Debón, R, Marsillach, J, Alonso-Villaverde, C, Mackness, B, Mackness, M, Pedro-Botet, J, Pardo-Reche, P, Joven, J, Camps, J. 01/01/2012. Journal Of Lipid Research. 53. PMID: 22003209. doi: 10.1194/jlr.P018457

    PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways

    Camps, J, García-Heredia, A, Rull, A, Alonso-Villaverde, C, Aragonès, G, Beltrán-Debón, R, Rodríguez-Gallego, E, Joven, J. 01/01/2012. Ppar Research. 2012. PMID: 22315585. doi: 10.1155/2012/616371

    Assessment of Compatibility between Extraction Methods for NMR- and LC/MS-Based Metabolomics

    Beltran, A, Suarez, M, Rodríguez, MA, Vinaixa, M, Samino, S, Arola, L, Correig, X, Yanes, O. 17/07/2012. Analytical Chemistry. 84. PMID: 22697410. doi: 10.1021/ac3005567

    Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

    Joven, J, Espinel, E, Rull, A, Aragonès, G, Rodríguez-Gallego, E, Camps, J, Micol, V, Herranz-López, M, Menéndez, JA, Borrás, I, Segura-Carretero, A, Alonso-Villaverde, C, Beltrán-Debón, R. 01/07/2012. Biochimica Et Biophysica Acta-General Subjects. 1820. PMID: 22503922. doi: 10.1016/j.bbagen.2012.03.020

    The Level of DING Proteins Is Increased in HIV-Infected Patients: In Vitro and In Vivo Studies

    Djeghader, A, Aragonés, G, Darbinian, N, Elias, M, Gonzalez, D, García-Heredia, A, Beltrán-Debón, R, Kaminski, R, Gotthard, G, Hiblot, J, Rull, A, Rohr, O, Schwartz, C, Alonso-Villaverde, C, Joven, J, Camps, J, Chabriere, E. 09/03/2012. Plos One. 7. PMID: 22427948. doi: 10.1371/journal.pone.0033062

    The Deleterious Influence of Tenofovir-Based Therapies on the Progression of Atherosclerosis in HIV-Infected Patients

    Aragonès, G, Pardo-Reche, P, Fernández-Sender, L, Rull, A, Beltrán-Debón, R, Rodríguez-Gallego, E, Camps, J, Joven, J, Alonso-Villaverde, C. 01/01/2012. Mediators Of Inflammation. 2012. PMID: 22645407. doi: 10.1155/2012/372305

    Human Duffy Blood Group Alloantigen System Influences the Measurement of Monocyte Chemoattractant Protein-1 (MCP-1) in Serum but not in Plasma

    Aragonès, G, Ercilla, A, Barreda, M, Rull, A, Beltrán-Debón, R, Rodríguez-Gallego, E, Alonso-Villaverde, C, Camps, J, Joven, J. 01/01/2012. Clinical Laboratory. 58. PMID: 22372364

    Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease

    García-Heredia, A, Marsillach, J, Aragonès, G, Guardiola, M, Rull, A, Beltrán-Debón, R, Folch, A, Mackness, B, Mackness, M, Pedro-Botet, J, Joven, J, Camps, J. 01/11/2011. Clinical Biochemistry. 44. PMID: 21854763. doi: 10.1016/j.clinbiochem.2011.08.003

    Antiretroviral treatment-induced dyslipidemia in HIV-infected patients is influenced by the APOC3-related rs10892151 polymorphism

    Aragonès, G, Alonso-Villaverde, C, Pardo-Reche, P, Rull, A, Beltrán-Debón, R, Rodríguez-Gallego, E, Fernández-Sender, L, Camps, J, Joven, J. 22/09/2011. Bmc Medical Genetics. 12. PMID: 21939545. doi: 10.1186/1471-2350-12-120

    Paraoxonase-1 is only present in traceable amounts in seminal fluid and does not show any relationship with male subfertility

    Marsillach, J, Lafuente, R, Checa, MA, Maestre-Martínez, C, Fabián, E, Brassesco, M, Beltrán-Debón, R, Aragonès, G, Carreras, R, Pedro-Botet, J, Joven, J, Camps, J. 01/08/2011. Bju International. 108. PMID: 21091978. doi: 10.1111/j.1464-410X.2010.09888.x

    MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND PARAOXONASE-1 IN PERIPHERAL ARTERIAL DISEASE: A MODEL OF INTERACTION BETWEEN DEFENSE AGAINST OXIDATIVE STRESS AND INFLAMMATION

    Rull, A, García, R, Fernández-Sender, L, Beltrán-Debón, R, Aragonès, G, Alegret, JM, Alonso-Villaverde, C, Mackness, M, Camps, J, Martin-Paredero, V, Joven, J. 01/06/2011. Atherosclerosis Supplements. 12. doi: 10.1016/S1567-5688(11)70416-0

    Measurement of serum PON-3 concentration: method evaluation, reference values, and influence of genotypes in a population-based study

    Aragonès, G, Guardiola, M, Barreda, M, Marsillach, J, Beltrán-Debón, R, Rull, A, Mackness, B, Mackness, M, Joven, J, Simó, JM, Camps, J. 01/05/2011. Journal Of Lipid Research. 52. PMID: 21335322. doi: 10.1194/jlr.D014134

    Bioavailability of phenols from a phenol-enriched olive oil

    Suárez, M, Valls, RM, Romero, MP, Macià, A, Fernández, S, Giralt, M, Solà, R, Motilva, MJ. 01/12/2011. BRITISH JOURNAL OF NUTRITION. 106. PMID: 21736768. doi: 10.1017/S0007114511002200

    The Role of Combined Assessment of Defense Against Oxidative Stress and Inflammation in the Evaluation of Peripheral Arterial Disease

    Rull, A, García, R, Fernández-Sender, L, Beltrán-Debón, R, Aragonès, G, Alegret, JM, Alonso-Villaverde, C, Mackness, B, Mackness, M, Camps, J, Martin-Paredero, V, Joven, J. 01/08/2011. Current Molecular Medicine. 11. PMID: 21663591. doi: 10.2174/156652411796268713

    Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis

    Joven, J, Espinel, E, Rull, A, Beltrán-Debón, R, Aragonès, G, Rodríguez-Gallego, E, Camps, J, Pedro-Botet, J, Sans, T, Menéndez, JA, Alonso-Villaverde, C. 01/07/2011. Journal Of Clinical Virology. 51. PMID: 21555238. doi: 10.1016/j.jcv.2011.04.003

    Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice

    Beltrán-Debón, R, Rull, A, Rodríguez-Sanabria, F, Iswaldi, I, Herranz-López, M, Aragonès, G, Camps, J, Alonso-Villaverde, C, Menéndez, JA, Micol, V, Segura-Carretero, A, Joven, J. 15/03/2011. Phytomedicine. 18. PMID: 21211952. doi: 10.1016/j.phymed.2010.11.008

    Immunohistochemical analysis of paraoxonases-1 and 3 in human atheromatous plaques

    Marsillach, J, Camps, J, Beltran-Debón, R, Rull, A, Aragones, G, Maestre-Martínez, C, Sabench, F, Hernández, M, Castillo, DD, Joven, J, Mackness, M, Mackness, B. 01/03/2011. European Journal Of Clinical Investigation. 41. PMID: 20964682. doi: 10.1111/j.1365-2362.2010.02411.x

    No Relationship Between TNF-a Genetic Variants and Combination Antiretroviral Therapy-Related Lipodystrophy Syndrome in HIV Type 1-Infected Patients: A Case-Control Study and a Meta-Analysis

    Veloso, S, Olona, M, Peraire, J, Viladés, C, Pardo, P, Domingo, P, Asensi, V, Broch, M, Aguilar, C, López-Dupla, M, Aragonés, G, Garcia-Pardo, G, Sirvent, JJ, Vendrell, J, Richart, C, Vidal, F. 01/02/2011. Aids Research And Human Retroviruses. 27. PMID: 20854131. doi: 10.1089/aid.2009.0312

    Differential response of two models of genetically modified mice fed with high fat and cholesterol diets: relationship to the study of non-alcoholic steatohepatitis

    Rodríguez-Sanabria, F, Rull, A, Aragonès, G, Beltrán-Debón, R, Alonso-Villaverde, C, Camps, J, Joven, J. 01/10/2010. Molecular And Cellular Biochemistry. 343. PMID: 20512524. doi: 10.1007/s11010-010-0498-2

    Decreased paraoxonase-1 activity is associated with alterations of high-density lipoprotein particles in chronic liver impairment

    Marsillach, J, Aragonès, G, Mackness, B, Mackness, M, Rull, A, Beltrán-Debón, R, Pedro-Botet, J, Alonso-Villaverde, C, Joven, J, Camps, J. 14/05/2010. Lipids In Health And Disease. 9. PMID: 20470383. doi: 10.1186/1476-511X-9-46

    Methodological constraints in interpreting serum paraoxonase-1 activity measurements: an example from a study in HIV-infected patients

    Parra, S, Marsillach, J, Aragonès, G, Rull, A, Beltrán-Debón, R, Alonso-Villaverde, C, Joven, J, Camps, J. 25/03/2010. Lipids In Health And Disease. 9. PMID: 20334696. doi: 10.1186/1476-511X-9-32

    Paraoxonase-1 Gene Haplotypes Are Associated with Metabolic Disturbances, Atherosclerosis, and Immunologic Outcome in HIV-Infected Patients

    Parra, S, Marsillach, J, Aragonés, G, Beltrán, R, Montero, M, Coll, B, Mackness, B, Mackness, M, Alonso-Villaverde, C, Joven, J, Camps, J. 15/02/2010. Journal Of Infectious Diseases. 201. PMID: 20078196. doi: 10.1086/650312

    Tissue distribution and expression of paraoxonases and chemokines in mouse: the ubiquitous and joint localisation suggest a systemic and coordinated role

    Rodríguez-Sanabria, F, Rull, A, Beltrán-Debón, R, Aragonès, G, Camps, J, Mackness, B, Mackness, M, Joven, J. 01/12/2010. Journal Of Molecular Histology. 41. PMID: 20931267. doi: 10.1007/s10735-010-9299-x

    Host-pathogen interactions in the development of metabolic disturbances and atherosclerosis in HIV infection: The role of CCL2 genetic variants

    Alonso-Villaverde, C, Aragonès, G, Beltrán-Debón, R, Fernández-Sender, L, Rull, A, Rodríguez-Sanabria, F, Marsillach, J, Pardo-Reche, P, Camps, J, Joven, J. 01/09/2010. Cytokine. 51. PMID: 20573518. doi: 10.1016/j.cyto.2010.05.008

    Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection

    Aragonès, G, Alonso-Villaverde, C, Oliveras-Ferraros, C, Beltrán-Debón, R, Rull, A, Rodríguez-Sanabria, F, Camps, J, Martín, AV, Menéndez, JA, Joven, J. 13/08/2010. Bmc Gastroenterology. 10. PMID: 20707918. doi: 10.1186/1471-230X-10-92

    Human immunodeficiency virus-infection induces major changes in high-density lipoprotein particle size distribution and composition: the effect of antiretroviral treatment and disease severity

    Aragonès, G, Beltrán-Debón, R, Rull, A, Rodríguez-Sanabria, F, Fernández-Sender, L, Camps, J, Joven, J, Alonso-Villaverde, C. 01/08/2010. Clinical Chemistry And Laboratory Medicine. 48. PMID: 20482383. doi: 10.1515/CCLM.2010.218

    THE EXPRESSION OF CYTOKINE GENES IN THE AORTA INFLUENCED BY DIET: THE EFFECT OF MCP-1 DEFICIENCY

    Rull, A, Beltrán-Debón, R, Aragonès, G, Rodríguez, F, Alonso-Villaverde, C, Camps, J, Joven, J. 10/06/2010. Atherosclerosis Supplements. 11. doi: 10.1016/S1567-5688(10)70632-2

    Expression of cytokine genes in the aorta is altered by the deficiency in MCP-1: Effect of a high-fat, high-cholesterol diet

    Rull, A, Beltrán-Debón, R, Aragonès, G, Rodríguez-Sanabria, F, Alonso-Villaverde, C, Camps, J, Joven, J. 01/05/2010. Cytokine. 50. PMID: 20207162. doi: 10.1016/j.cyto.2010.02.010

    Nonconcordance between subclinical atherosclerosis and the calculated Framingham risk score in HIV-infected patients: relationships with serum markers of oxidation and inflammation

    Parra, S, Coll, B, Aragonés, G, Marsillach, J, Beltrán, R, Rull, A, Joven, J, Alonso-Villaverde, C, Camps, J. 01/04/2010. Hiv Medicine. 11. PMID: 19845792. doi: 10.1111/j.1468-1293.2009.00766.x

    Pitfalls in measuring high-density lipoprotein cholesterol concentrations in HIV-infected patients

    Aragonès, G, Beltrán, R, Rull, A, Marsillach, J, Rodríguez, F, Alí, SB, Fernández-Sender, L, Camps, J, Joven, J, Alonso-Villaverde, C. 01/04/2010. Hiv Medicine. 11. PMID: 20002780. doi: 10.1111/j.1468-1293.2009.00772.x

    Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis

    Marsillach, J, Oliveras-Ferraros, C, Beltrán, R, Rull, A, Aragonès, G, Alonso-Villaverde, C, Vázquez-Martín, A, Joven, J, Menéndez, JA, Camps, J. 01/09/2009. Clinical Chemistry And Laboratory Medicine. 47. PMID: 19728851. doi: 10.1515/CCLM.2009.259

    Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography-tandem mass spectrometry

    Suárez, M, Romero, MP, Macià, A, Valls, RM, Fernández, S, Soià, R, Motilva, MJ. 15/12/2009. Journal Of Chromatography B-Analytical Technologies In The Biomedical And Life Sciences. 877. PMID: 19913464. doi: 10.1016/j.jchromb.2009.10.025

    Hepatic monocyte chemoattractant protein-1 is upregulated by dietary cholesterol and contributes to liver steatosis

    Rull, A, Rodríguez, F, Aragonès, G, Marsillach, J, Beltrán, R, Alonso-Villaverde, C, Camps, J, Joven, J. 01/12/2009. Cytokine. 48. PMID: 19748796. doi: 10.1016/j.cyto.2009.08.006

    PPAR? Pro12Ala Polymorphism in HIV-1-Infected Patients with HAART-Related Lipodystrophy

    Saumoy, M, Veloso, S, Alonso-Villaverde, C, Domingo, P, Chacón, MR, Miranda, M, Broch, M, Aragonès, G, Gutiérrez, MM, Viladés, C, Peraire, J, Sirvent, JJ, López-Dupla, M, Aguilar, C, Auguet, T, Vendrell, J, Olona, M, Richart, C, Vidal, F. 01/09/2009. Current Hiv Research. 7. PMID: 19534662. doi: 10.2174/157016209789346219

    The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment

    Marsillach, J, Aragonès, G, Beltrán, R, Caballeria, J, Pedro-Botet, J, Morcillo-Suárez, C, Navarro, A, Joven, J, Camps, J. 01/01/2009. Clinical Biochemistry. 42. PMID: 18977341. doi: 10.1016/j.clinbiochem.2008.09.120

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