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Recerca en Patologia Oncològica i Bioinformàtica (PO&B)

GRUPS CLÍNICS
ONCOLOGIA BIOINFORMÀTICA OTORINOLARINGOLOGIA ANESTESIOLOGIA
OBJECTIUS

• Identificar poblacions cel·lulars immunes y marcadors moleculars del microambient tumoral y dels ganglis limfàtics, que juntament amb la informació clinico-patològica tinguin un valor pronòstic i predictiu en la supervivència i recaiguda de les pacients amb càncer de mama i limfomes. Aquesta identificació pot ajudar a entendre els mecanismes biològics implicats en la resistència als tractaments i l’obtenció de noves dianes terapèutiques, a més de poder esdevenir nous factors claus en el diagnòstic, pronòstic i tractament d’aquests pacients.

• Desenvolupar i perfeccionar nous procediments d’anàlisi d’imatges histològiques digitals mitjançant tècniques d’intel·ligència artificial i/o amb tècniques d’anàlisi d’imatges digitals clàssiques. Aquests procediments permeten una quantificació automatitzada més precisa i reproduïble de les poblacions cel·lulars immunes y dels marcadors moleculars presents en el microambient tumoral y dels ganglis limfàtics.

• Elaborar models predicitus relacionats amb la supervivència i recaiguda de les pacients amb càncer de mama i limfomes, mitjançant mètodes estadístics clàssics i/o amb intel·ligència artificial, intengrant la informació clínico-patológica, de resposta immune y de marcadors moleculars.

• Modelitzar computacionalment el microambient tumoral en càncer de mama tant el tumor primàri com en el gangli limfàtic axil·lar mitjançant models basats en agents. Aquests models computacionals permetran la simulació de les accions i de les interaccions de les poblacions immunes y dels marcadors moleculars, per veure quins efectes produeixen en el conjunt del sistema.

RESPONSABLES

  • Marylène Lejeune

  • Carlos López Pablo

  • Presentació
  • Línies
  • Membres del grup
  • Membres del grup+
  • Publicacions
  • Projectes
  • Ofertes laborals
  • Publicacions+
  • Contactar

L’equip PO&B de l’IISPV, amb seu a l’Hospital de Tortosa Verge de la Cinta, treballa des de fa més de 15 anys en la prevenció i el diagnòstic avançat del càncer. Liderat per la Dra. Marylène Lejeune i el Dr. Carlos López, l’equip PO&B és un grup interdisciplinari que inclou patòlegs, oncòlegs, hematòlegs, biòlegs i especialistes en informàtica, amb habilitats clíniques i metodològiques estratègiques per al desenvolupament de les línies de recerca del grup. Durant tots aquests anys, el grup ha tingut diferents projectes finançats conjuntament amb col·laboradors nacionals (Universitat Rovira i Virgili [URV] de Tarragona; Universidad de Castilla-la Mancha; Hospital Universitario Puerta del Mar de Cadis; Universidad de Las Palmas de Gran Canaria) i internacionals (Nalecz Institute of Biocybernetics and Biomedical Engineering de Varsòvia, Polònia; Université de Caen, França).

Les línies de recerca consolidades de l’equip PO&B se centren en l’estudi del microambient tumoral mitjançant anàlisi d’imatges digitals i modelatge matemàtic. La resposta immune és un dels components del microambient tumoral que s’ha demostrat que exerceix un paper important en l’evolució de pacients amb càncer. Els canvis en el tipus i la quantitat de cèl·lules immunes al microambient tumoral han estat relacionats amb diferències en la funcionalitat de la malaltia. El nostre equip ha estudiat aquests canvis gràcies al desenvolupament de nous algoritmes d’anàlisi d’imatges assistides per ordinador capaços de proporcionar una quantificació automatitzada més precisa i reproduïble de biomarcadors immunes amb una tinció immunohistoquímica i de fluorescència.

El grup PO&B és reconegut com a grup URV des de 2016, com a grup emergent des de 2009 i consolidat des de 2014 per l’Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR). Els membres de l’equip coordinen també la plataforma transversal i de suport de l’IISPV per a estudis histològics, patològics i de digitalització.

El grup treballa amb l’objectiu estratègic de millorar l’administració dels tractaments actuals en càncer i detectar noves dianes terapèutiques en càncer de mama i en limfomes per poder disminuir el risc de recaiguda i millorar la supervivència dels pacients. Les línies d’investigació del grup són les següents:

1) Estudi de patrons de biomarcadors del microambient tumoral. L’objectiu d’aquesta línia d’investigació és  identificar patrons de resposta immune del microambient tumoral i de factors etiològics, fisiopatogènics i pronòstics lligats a models de progressió de neoplàsies (càncer de mama i síndromes limfoproliferatius). Aquests objectius poden ajudar a entendre els mecanismes biològics implicats en la resistència a la quimioteràpia i l’obtenció de noves dianes terapèutiques amb capacitat d’intervenció, a més de la constitució de nous factors claus en el diagnòstic, pronòstic i tractament d’aquests pacients.

2) Morfometria i informàtica aplicada. L’objectiu d’aquest línia d’investigació és desenvolupar i perfeccionar nous suports informàtics d’anàlisi d’imatge assistit per ordinador per permetre una quantificació automatitzada més precisa i reproduïble de biomarcadors de cèl·lules tumorals i hoste del microambient tumoral amb tincions inmmunohistoquímiques i de fluorescència.

3) Recerca translacional en malalties hematològiques: avaluació de protocols diagnòstics i de tractaments. L’objectiu d’aquesta línia d’investigació és ampliar el coneixement previ existent de les malalties de la sang, de nous procediments idonis per al seu diagnòstic i, molt especialment, de nous tractaments que permetin la curació o almenys perllongar la vida de les persones que pateixen una malaltia hematològica sigui neoplàstica o no.

Investigador: María Teresa Giménez Pérez (id: 110274), Daniel Mata Cano (id: 110372), Carlos López Pablo (id: 110949), Marylène Marie Lejeune (id: 110934), Jordi Baucells Lluís (id: 110642), Montserrat Llobera Serentill (id: 110940), Jesús Xavier Ortín Font (id: 111055), Marta Rodríguez Luaces (id: 111144), Esther Sauras Colom (id: 110516), Ramon Bosch Príncep (id: 111287), Miriam José De La Flor López (id: 110758), Noelia Gallardo Borràs (id: 111324), Elena Goyda (id: 111325), José Antonio Izuel Navarro (id: 111326), Valerie Rodríguez Guzmán (id: 111327), Alessio Florin (id: 111698), Laia Adalid Llansa (id: 111386), Júlia Casanova Ribes (id: 110184), Montserrat Salvadó Piñol (id: 110500), Tábata Sánchez Alcántara (id: 111889)

    Año

    Clustered nuclei splitting based on recurrent distance transform in digital pathology images.

    Autors: Lukasz Roszkowiak L, KorzynskaA, Pijanowska D, Bosch R, Lejeune M, Lopez C.

    Revista: EURASIP Journal on Image and Video Processing

    Any i pàgina: EURASIP Journal on Image and Video Processing volume 2020, Article number: 26 (2020)

    https://rd.springer.com/article/10.1186/s13640-020-00514-6

    Integrating the tumor microenvironment into cancer therapy.

    Autors: Sanegre S, Lucantoni F, Burgos-Panadero R, de La Cruz-Merino L, Noguera R, Álvaro Naranjo T.

    Revista: Cancers (Basel)

    Any i pàgina: 2020 Jun 24;12(6). pii: E1677. doi: 10.3390/cancers12061677

    Hyperspectral imaging and deep learning for the detection of breast cancer cells in digitized histological images

    Autors: Ortega S, Halicek M, Fabelo H, Guerra R, Lopez C, Lejaune M, Godtliebsen F, Callico GM, Fei B.

    Revista: Proc SPIE Int Soc Opt Eng

    Any i pàgina: 2020 Feb;11320. pii: 113200V. doi: 10.1117/12.2548609.

    An integral view of cancer (III). Evaluation of new biomarkers and treatment strategies

    Autors: Noguera R, Burgos-Panadero R, Lucantoni F, de la Cruz-Merino L, Álvaro Naranjo T.

    Revista: Rev Esp Patol

    Any i pàgina: 2020 Apr – Jun;53(2):88-99. doi: 10.1016/j.patol.2019.08.001. Epub 2019 Nov 22

    Conditional generative adversarial network for synthesizing hyperspectral images of breast cancer cells from digitized histology.

    Autors: Halicek M, Ortega S, Fabelo H, Lopez C, Lejaune M, Callico GM, Fei B.

    Revista: Proc SPIE Int Soc Opt Eng

    Any i pàgina: 2020 Feb;11320. pii: 113200U. doi: 10.1117/12.2549994.

     

    Application of a digital PCR method for WT1 to myeloid neoplasms in CR and deep ELN WT1 molecular response (<10 copies).

    Autors: Bussaglia E, Pratcorona M, Carricondo M, Sansegundo L, Rubio MA, Monter A, Brell A, Badell I, Esteve J, Arnan M, Talarn C, Tormo M, García A, Vall-Llovera F, Ortin X, Pedro C, Bargay J, Brunet S, Sierra J, Nomdedéu J.

    Revista: Ann Hematol

    Any i pàgina: 2020 Apr;99(4):765-772. doi: 10.1007/s00277-020-03910-0. Epub 2020 Feb 15.

    Differences in the immune response of the non-metastatic axillary lymph nodes between triple-negative and luminal A breast cancer surrogate subtypes.

    López C, Gibert-Ramos A, Bosch R, Korzynska A, García-Rojo M, Bueno G, García-Fontgivell JF, González SM, Fontoura L, Navarro AG, Colón ES, Ribes JC, Roszkowiak L, Roso A, Berenguer M, Llobera M, Baucells J, Lejeune M.
    2020 Dec 10 [Epub ahead of print]. Am J Pathol
    DOI: 10.1016/j.ajpath.2020.11.008

    The Immune Response in Nonmetastatic Axillary Lymph Nodes Is Associated with the Presence of Axillary Metastasis and Breast Cancer Patient Outcome

    López C, Bosch R, Orero G, Korzynska A, García-Rojo M, Bueno G, Fernández-Carrobles MDM, Gibert-Ramos A, Roszkowiak L, Callau C, Fontoura L, Salvadó MT, Álvaro T, Jaén J, Roso-Llorach A, Llobera M, Gil J, Onyos M, Plancoulaine B, Baucells J, Lejeune M.
    Am J Pathol. 2020 Mar;190(3):660-673.
    DOI: 10.1016/j.ajpath.2019.11.002

     

    Potential Molecular Players of the Tumor Microenvironment in Extracranial Pediatric Solid Tumors.

    Noguera R, Álvaro Naranjo.
    Cancers (Basel). 2020 Oct 9;12(10):2905.
    DOI: 10.3390/cancers12102905

     

    Comparative clinical prognosis of massive and non-massive pulmonary embolism: a registry-based cohort study.

    Blondon M, Jimenez D, Robert-Ebadi H, Del Toro J, Lopez-Jimenez L, Falga C, Skride A, Font L, Vazquez FJ, Bounameaux H, Monreal M; RIETE investigators.
    2020 Dec 19 [Epub ahead of print]. J Thromb Haemost
    DOI: 10.1111/jth.15146

     

    Peritumoral immune infiltrates in primary tumours are not associated with the presence of axillary lymph node metastasis in breast cancer: a retrospective cohort study

    López C, Bosch-Príncep R, Orero G, Fontoura Balagueró L, Korzynska A, García-Rojo M, Bueno G, Fernández-Carrobles MDM, Roszkowiak L, Callau Casanova C, Salvadó-Usach MT, Jaén Martínez J, Gibert-Ramos A, Roso-Llorach A, Gras Navarro A, Berenguer-Poblet M, Llobera M, Gil Garcia J, Tomás B, Gestí V, Laine E, Plancoulaine B, Baucells J, Lejeune M.
    PeerJ. 2020 Sep 2;8:e9779.
    DOI: 10.7717/peerj.9779

     

    Increased survival time or better quality of life? Trade-off between benefits and adverse events in the systemic treatment of cancer.

    Valentí V, Ramos J, Pérez C, Capdevila L, Ruiz I, Tikhomirova L, Sánchez M, Juez I, Llobera M, Sopena E, Rubió J, Salazar R.
    Clin Transl Oncol. 2020 Jun;22(6):935-942.
    DOI: 10.1007/s12094-019-02216-6

    Impact of Implementing a Dyslipidemia Management Guideline on Cholesterol Control for Secondary Prevention of Ischemic Heart Disease in Primary Care.

    Forcadell Drago E, Dalmau Llorca MR, Aguilar Martín C, Ferreira-González I, Hernández Rojas Z, Gonçalves AQ, López-Pablo C.
    Int J Environ Res Public Health. 2020 Nov 19;17(22):8590.
    DOI: 10.3390/ijerph17228590

     

    Coping Strategies, Quality of Life, and Neurological Outcome in Patients Treated with Mechanical Thrombectomy after an Acute Ischemic Stroke.

    S Reverté-Villarroya, A Dávalos, S Font-Mayolas, M Berenguer-Poblet, E Sauras-Colón, C López-Pablo, E Sanjuan-Menéndez , L Muñoz-Narbona, R Suñer-Soler
    Int J Environ Res Public Health. 2020 Aug 19;17(17):6014.
    DOI: 10.3390/ijerph17176014

     

    Developing indicators for quality assurance in cytopathology.

    Tresserra F,  Temprana  J, Vasquez C, Lloveras B, Català I,  Tarroch X, Combalia N,  Alameda F,  Bosch R, Gallardo J, Mancebo E,  Fabra G, Dinares MC, Santacana M,  Gonzalez C, Pérez-Ochoa F.
    2020 Oct 19 [Epub ahead of print]. Diagn Cytopathol
    DOI: 10.1002/dc.24639

     

     

    Differential characteristics of the typical and atypical advanced interatrial block

    Gentille-Lorente D, Salvadó-Usach T.
    Arch Cardiol Mex. 2020;90(3):266-273.
    DOI: 10.24875/ACM.20000240

    [Clinical, electrical and echocardiographic characteristics of patients with advanced interatrial block]

    Gentille-Lorente D, Salvadó-Usach T.
    Arch Cardiol Mex. 2020 Nov 24;91(1):135-138.
    DOI: 10.24875/ACM.20000239

     

    The immune response in non-metastatic axillary lymph nodes is associated with the presence of axillary metastasis and breast cancer patient outcome

    Autors: López C, Bosch R, Orero G, Korzynska A, García-Rojo M, Bueno G, Fernández-Carrobles MM, Gibert-Ramos A, Roszkowiak L, Callau C, Fontoura L, Salvadó MT, Álvaro T, Jaén J, Roso-Llorach A, Llobera M, Gil J, Onyos M,  Plancoulaine B,  Baucells J, Lejeune M.

    Revista: Am J Pathol

    Any i pàgina: 2019 Dec 19. pii: S0002-9440(19)30860-0. doi: 10.1016/j.ajpath.2019.11.002.

    Immune response profile of primary tumour, sentinel and non-sentinel axillary lymph nodes related to metastasis in breast cancer: An immunohistochemical point of view

    Autors: Gibert-Ramos A, López C, Bosch R, Fontoura L, Bueno G, García-Rojo M, Berenguer M, Lejeune M.

    Revista: Histochem Cell Biol

    Any i pàgina: 2019 Jul 13. doi: 10.1007/s00418-019-01802-7

    The Tumour microenvironment as an integrated framework to understand cancer biology

    Autors: Burgos-Panadero R, Lucantoni F, Gamero-Sandemetrio E, Cruz-Merino L, Naranjo TÁ, Noguera R.

    Revista: Cancer Lett

    Any i pàgina: 2019 Jul 17. pii: S0304-3835(19)30406-9. doi: 10.1016/j.canlet.2019.07.010

    An integral view of cancer (I). The study, classification and reprogramming of the tumoral microclimate

    Autors: Noguera R, Burgos-Panadero R, Gamero-Sandemetrio E, de la Cruz-Merino L, Álvaro Naranjo T.

    Revista: Rev Esp Patol

    Any i pàgina: 2019 Apr – Jun;52(2):92-102. doi: 10.1016/j.patol.2018.11.003. Epub 2019 Feb 10

    An integral view of cancer (II). Fields of investigation and emerging biomarkers

    Autors: Noguera R, Burgos-Panadero R, Gamero-Sandemetrio E, de la Cruz-Merino L, Álvaro Naranjo T.

    Revista: Rev Esp Patol

    Any i pàgina: 2019 Oct – Dec;52(4):222-233. doi: 10.1016/j.patol.2019.04.005. Epub 2019 Jun 11

    The medicine of cancer: Can the solutions be found in our own back yard?

    Autors: Naranjo T.

    Revista: Rev Esp Patol

    Any i pàgina: 2019 Apr – Jun;52(2):69-71. doi: 10.1016/j.patol.2018.10.004.

    The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

    Autors: Ribera J, Granada I, Morgades M, Vives S, Genescà E, González C, Nomdedeu J, Escoda L, Montesinos P, Mercadal S, Coll R, González-Campos J, Abella E, Barba P, Bermúdez A, Gil C, Tormo M, Pedreño M, Martínez-Carballeira D, Hernández-Rivas JM, Orfao A, Martínez-López J, Esteve J, Bravo P, Garcia-Guiñon A, Debén G, Moraleda JM, Quiezán JA, Ortín X, Moreno MJ, Feliu E, Solé F, Ribera JM; PETHEMA Group, Spanish Society of Haematology.

    Revista: Br J Haematol

    Any i pàgina: 2019 Jul;186(2):263-268. doi: 10.1111/bjh.15887.

    Prediction of early mortality in patients with cancer-associated thrombosis in the RIETE database

    Autors: Fuentes HE, Tafur AJ, Caprini JA, Alatri A, Trujillo-Santos J, Farge-Bancel D, Rosa V, Font L, Vilaseca A, Monreal M; RIETE Investigators.

    Revista: Int Angiol

    Any i pàgina: 2019 Jun;38(3):173-184. doi: 10.23736/S0392-9590.19.04110-5

    Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring

    Autors: Algaba-Chueca F, Maymó-Masip E, Ejarque M, Ballesteros M, Llauradó G, López C, Guarque A, Serena C, Martínez-Guasch L, Gutiérrez C, Bosch R, Vendrell J, Megía A, Fernández-Veledo S.

    Revista: Stem Cells Transl Med

    Any i pàgina: 2019 Dec 27. doi: 10.1002/sctm.19-0242

    Ten-year follow-up of clinical governance implementation in primary care: Improving screening, diagnosis and control of cardiovascular risk factors

    Autors: Aguilar Martín C, Gonçalves AQ, López-Pablo C, Fernández-Sáez J, Forcadell Drago E, Hernández Rojas Z, Pepió Vilaubí JM, Rodríguez Cumplido D, Piñol JL, Bladé-Creixenti J, Dalmau Llorca MR

    Revista: Int J Environ Res Public Health

    Any i pàgina: 2019 Nov 5;16(21). pii: E4299. doi: 10.3390/ijerph16214299

  • Title: Nous motlles de matrius multiteixit per investigar i millorar la qualitat assistencial en estudis histologics de cancer i altres malalties (tmatech mold)

    Funding entity: FUNDACIO INSTITUCIO DELS CENTRES DE RECERCA DE CATALUNYA

    Duration: 2025-2027

    Principal Investigator: LOPEZ PABLO, CARLOS

  • Title: 2023 prod 00085 ajuts producte motlles emma carlos lopez

    Funding entity: AGENCIA DE GESTIO D’AJUTS UNIVERSITARIS I DE RECERCA

    Duration: 2024-2027

    Principal Investigator: LOPEZ PABLO, CARLOS

    Investigators: , FERRI MARZO, ROSENDO JESUS; GALLARDO BORRAS, NOELIA; GUILERA MORILLA, MARIA JOSE; SANCHEZ ALCANTARA, TABATA; SAURAS COLOM, ESTHER

  • Title: 2021 llav 00051 ajuts d’industria del coneixement per a l’any 2021. modalitat a. ajuts llavor. impressio de motlles en 3d per analisis histologics. acronym: motlles 3d

    Funding entity: AGENCIA DE GESTIO D’AJUTS UNIVERSITARIS I DE RECERCA

    Duration: 2022-2023

    Principal Investigator: LOPEZ PABLO, CARLOS

    Investigators: BESALDUCH PIÑOL, FRANCISCO JOSE; FERRI MARZO, ROSENDO; SALVADO PIÑOL, MONTSERRAT; SAURAS COLOM, ESTHER; SOBRINO LACRUZ, AGUSTI

  • Title: Ted2021-130081b-c22 proyectos de transicion ecologica y transicion digital 2021

    Funding entity: MINISTERIO DE CIENCIA Y TECNOLOGIA

    Duration: 2022-2027

    Principal Investigator: LOPEZ PABLO, CARLOS

    Investigators: , GALLARDO BORRAS, NOELIA; , SAURAS COLOM, ESTHER; AMILLANO PARRAGA, KEPA; BOSCH PRINCEP, RAMON; GARCIA FONTGIVELL, JOAN FRANCESC; GARCIA ROJO, MARCIAL; GUMÀ PADRÓ, JOSÉ; LANDEYRO NUÑEZ, JULIETA; LEJEUNE, MARYLENE; LLOBERA SERENTILL,MONTSERRAT; MARTÍNEZ GONZÁLEZ, MARÍA SALOMÉ; MATA CANO, DANIEL; MELE OLIVE, MIREIA; PARADA DOMINGUEZ, DAVID; PEÑA GONZALEZ, KARLA BEATRIZ; REVERTE CLAVET, LAIA; RIU FERRANDO, FRANCISCO PEDRO

  • Title: A comprehensive cad system based on radiologic- and pathologic-image biomarkers for diagnosis and prognosis of breast cancer relapse (bosomshield)

    Funding entity: COMMISSION OF THE EUROPEAN COMMUNITIES

    Duration: 2022-2028

    Principal Investigator: LOPEZ PABLO, CARLOS

    Investigators: ADALID LLANSA, LAIA; BOSCH CALERO, RAMON; FIORIN , ALESSIO; LEJEUNE, MARYLENE; REVERTÉ VILLARROYA, SILVIA

  • Title: 2021 sgr 00319 grup de recerca sonsolidat (grc) opcio reconeixement sense finançament (validacio tecnica) iispv

    Funding entity: AGENCIA DE GESTIO D’AJUTS UNIVERSITARIS I DE RECERCA

    Duration: 2022-2027

    Principal Investigator: LEJEUNE, MARYLENE

    Investigators: ALVARO NARANJO, TOMAS; BAUCELLS LLUÍS,JORDI; BOSCH PRÍNCEP, RAMON; DE LA FLOR LÓPEZ, MIRIAM JOSÉ; GALLARDO BORRAS, NOELIA; GIMENEZ PEREZ, MARIA TERESA; GOYDA , ELENA; LLOBERA SERENTILL,MONTSERRAT; LOPEZ PABLO, CARLOS; MATA CANO, DANIEL; ORTIN FONT, JESUS XAVIER; REVERTE CALVET, LAIA; RIZO BARRIOS, ANTONIO; RODRIGUEZ GUZMAN, VALERIE; RODRIGUEZ LUACES, MARTA; SAURAS COLOM, ESTHER

    Año

    A modular deep learning pipeline for stromal TILs scoring in breast cancer H&E slides.

    Abdelazeez S, Ahmed F, Adalid L, Siemion K, Lopez C, Lejeune M, Rashwan H, Korzynska A. 01/08/2026. Computer Methods And Programs In Biomedicine. 282. PMID: 42013559. doi: 10.1016/j.cmpb.2026.109374

    Towards Breast Tumor Aggressiveness Classification in Digital Mammograms Using Boundary-Aware Segmentation and Feature Analysis

    Khalid, A, Mursil, M, Okran, AM, Padro, JG, Pablo, CL, Puig, D, Rashwan, HA. 01/01/2026. Medical Image Understanding And Analysis, Miua 2025, Pt Ii. 15917. doi: 10.1007/978-3-031-98691-8_12

    Influence of the Molecular Subtype-Dependent Immune Microenvironment of Metastatic Axillary Lymph Nodes on Breast Cancer Patient Outcomes.

    López C, Reverté L, Bosch Príncep R, Sauras E, Gallardo-Borràs N, Fischer-Carles A, Korzynska A, García-Rojo M, Bueno G, Roszkowiak L, Roso-LLorach A, Gras Navarro A, Llobera M, Mata D, Adalid Llansa L, Martínez-González S, Garcia-Fontgivell JF, Arenas M, Gómez J, Izuel JA, Baucells J, Lejeune M. 31/12/2025. Pathobiology. PMID: 41474659. doi: 10.1159/000550086

    Cell populations in human breast cancers are molecularly and biologically distinct with age

    Parsons, A, Colón, ES, Manjunath, M, Zhang, HY, Chen, JL, Spasic, M, Koca, B, Kurt, BB, Freedman, RA, Mittendorf, EA, Swarbrick, A, van Galen, P, McAllister, SS. 01/12/2025. Nature Aging. 5. PMID: 41188599. doi: 10.1038/s43587-025-00984-1

    Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group.

    Colbert SMC, Monson ET, Andreassen OA, Ayinde OO, Barr PB, Bejan CA, Ceja Z, Coon H, DiBlasi E, Edenberg HJ, Gelernter J, Hatoum A, Izotova A, Johnson EC, Kaufman EA, Kranzler HR, Koromina M, Lehto K, Myung W, Nurnberger JI Jr, Serretti A, Smoller JW, Stein MB, Zai CC, Erlangsen A, Gaine M, Martorell L, Sud R, Toma C, Bigdeli TB, Kimbrel NA, Ruderfer D, Docherty AR, Mann JJ, Mullins N. 01/12/2025. Molecular Psychiatry. 30. PMID: 40999039. doi: 10.1038/s41380-025-03271-y

    Histological Hyperspectral Breast Cancer Recurrence Database (HistologyHSI-BC Recurrence)

    Quintana-Quintana, L, Sauras-Colon, E, Fiorin, A, Santana-Nunez, J, Ortega, S, Gallardo-Borràs, N, Fischer-Carles, A, Sánchez-Alcántara, T, Fabelo, H, Adalid-Llansa, L, Mata-Cano, D, Bosch-Príncep, R, Lejeune, M, Callico, GM, Lopez-Pablo, C. 28/11/2025. Scientific Data. 12. PMID: 41315494. doi: 10.1038/s41597-025-06157-4

    Advancing breast cancer relapse prediction with radiomics and neural networks: a clinically interpretable framework.

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    Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome

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    Multidisciplinary rehabilitation treatments for patients with fibromyalgia: a systematic review

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    Immunometabolism Modulation in Therapy.

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    Obesity induces pro-tumoral programming of macrophages by a survivin-dependent mechanism

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    Influence of Pain and Discomfort in Stroke Patients on Coping Strategies and Changes in Behavior and Lifestyle

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    Emergency handover of critical patients. A systematic review

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    Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction

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    System for quantitative evaluation of DAB&H-stained breast cancer biopsy digital images (CHISEL)

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    Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker

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    e-Thrombosis in the COVID-19 era: collateral effects of confinement

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    Differences in the Immune Response of the Nonmetastatic Axillary Lymph Nodes between Triple-Negative and Luminal A Breast Cancer Surrogate Subtypes

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    Instrumentation Evaluation for Hyperspectral Microscopy Targeting Enhanced Medical Histology

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    Circulating myeloid-derived suppressor cells and regulatory T cells as immunological biomarkers in refractory/relapsed diffuse large B-cell lymphoma: translational results from the R2-GDP-GOTEL trial

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    A Time-Distributed Convolutional Long Short-Term Memory for Hand Gesture Recognition

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    Convexity shape constraints for retinal blood vessel segmentation and foveal avascular zone detection.

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    Impact of Implementing a Dyslipidemia Management Guideline on Cholesterol Control for Secondary Prevention of Ischemic Heart Disease in Primary Care.

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    Potential Molecular Players of the Tumor Microenvironment in Extracranial Pediatric Solid Tumors

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    Coping Strategies, Quality of Life, and Neurological Outcome in Patients Treated with Mechanical Thrombectomy after an Acute Ischemic Stroke

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    Validation of a Deep Learning Algorithm for Diabetic Retinopathy.

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    Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring.

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    The Immune Response in Nonmetastatic Axillary Lymph Nodes Is Associated with the Presence of Axillary Metastasis and Breast Cancer Patient Outcome

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    Lenalidomide plus R-GDP (R2-GDP) in relapsed/refractory diffuse large B-cell lymphoma: Final results of the R2-GDP-GOTEL trial.

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    Immune response profile of primary tumour, sentinel and non-sentinel axillary lymph nodes related to metastasis in breast cancer: an immunohistochemical point of view.

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    Gestational diabetes impacts foetal progenitor cell responses with consequences for offspring

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    A Clinical Decision Support System for Diabetic Retinopathy Screening: Creating a Clinical Support Application.

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    Stakeholders Acceptance and Expectations of Robot-Assisted Therapy for Children with Autism Spectrum Disorder

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    A systematic, international review of recent research on multidisciplinary treatments for patients with fibromyalgia: research outcomes of policy-based recommendations

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    MIDOSTAURIN ASSOCIATED WITH INTENSIVE CHEMOTHERAPY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA WITH NEW DIAGNOSIS WITH FLT3 MUTATION. EXPERIENCE IN "REAL LIFE"

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    Comparative Study of the Behavior of Feature Reduction Methods in Person Re-identification Task

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    Individualized 3D scanning and printing for non-melanoma skin cancer brachytherapy: a financial study for its integration into clinical workflow

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    PATMA: parser of archival tissue microarray

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    Differences between MDRD-4 and CG in the prevalence of renal failure and its associated variables in type 2 diabetic patients

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    Cost of diabetic retinopathy and macular oedema in a population, an eight year follow up

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    Interactive Optic Disk Segmentation via Discrete Convexity Shape Knowledge Using High-Order Functionals

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    Thrombolysis Therapy after a First Acute Ischemic Stroke: Sex Differences in Lomg Time Survival and Disability. Ebrictus Study

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    Undiagnosed Atrial Fibrillation in Adults added Ineffectiveness of Oral Anticoagulation Treatment with VKA

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    Sex Differences in Long-Term Survival after a First Stroke with Intravenous Thrombolysis: Ebrictus Study.

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    Evaluation of cytokeratin-19 in breast cancer tissue samples: a comparison of automatic and manual evaluations of scanned tissue microarray cylinders

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    Correlation between mutational status and survival and second cancer risk assessment in patients with gastrointestinal stromal tumors: a population-based study

    Rubió-Casadevall, J, Borràs, JL, Carmona-García, MC, Ameijide, A, Gonzalez-Vidal, A, Ortiz, MR, Bosch, R, Riu, F, Parada, D, Marti, E, Miró, J, Sirvent, JJ, Galceran, J, Marcos-Gragera, R. 13/02/2015. World Journal Of Surgical Oncology. 13. PMID: 25885906. doi: 10.1186/s12957-015-0474-0

    Differences in the survival after an episode of stroke treated with thrombolytic therapy. Study Ebrictus

    Clua-Espuny, JL, Ripolles-Vicente, R, Lopez-Pablo, C, Panisello-Tafalla, A, Lucas-Noll, J, Calduch-Noll, C, González-Henares, MA, Queralt-Tomas, ML. 01/02/2015. Atencion Primaria. 47. PMID: 24953174. doi: 10.1016/j.aprim.2014.04.008

    Results from the Registry of Atrial Fibrillation (AFABE): Gap between Undiagnosed and Registered Atrial Fibrillation in Adults-Ineffectiveness of Oral Anticoagulation Treatment with VKA

    Panisello-Tafalla, A, Clua-Espuny, JL, Gil-Guillen, VF, González-Henares, A, Queralt-Tomas, ML, López-Pablo, C, Lucas-Noll, J, Lechuga-Duran, I, Ripolles-Vicente, R, Carot-Domenech, J, López, MG. 01/01/2015. BioMed research international. 2015. PMID: 26229954. doi: 10.1155/2015/134756

    Biotensegrity of the extracellular matrix: physiology, dynamic mechanical balance, and implications in oncology and mechanotherapy.

    Tadeo I, Berbegall AP, Escudero LM, Alvaro T, Noguera R. 04/03/2014. Frontiers in oncology. 4. PMID: 24624363. doi: 10.3389/fonc.2014.00039

    The management of atrial fibrillation and characteristics of its current care in outpatients. AFABE observational study

    Giménez-García, E, Clua-Espuny, JL, Bosch-Príncep, R, López-Pablo, C, Lechuga-Durán, I, Gallofré-López, M, Panisello-Tafalla, A, Lucas-Noll, J, Queralt-Tomas, ML. 01/02/2014. Atencion Primaria. 46. PMID: 24042075. doi: 10.1016/j.aprim.2013.06.003

    Diagnosed, Identified, Current and Complete Depression Among Patients Attending Primary Care in Southern Catalonia: Different Aspects of the Same Concept

    Montesó-Curto, P, Ferré-Grau, C, Lleixà-Fortuño, M, Albacar-Riobóo, N, Lejeune, M. 01/02/2014. Archives Of Psychiatric Nursing. 28. PMID: 24506987. doi: 10.1016/j.apnu.2013.10.002

    Development of automated quantification methodologies of immunohistochemical markers to determine patterns of immune response in breast cancer: a retrospective cohort study

    López, C, Callau, C, Bosch, R, Korzynska, A, Jaén, J, García-Rojo, M, Bueno, G, Salvadó, MT, Alvaro, T, Oños, M, Fernández-Carrobles, MD, Llobera, M, Baucells, J, Orero, G, Lejeune, M. 01/01/2014. BMJ Open. 4. PMID: 25091015. doi: 10.1136/bmjopen-2014-005643

    Evaluation of Cytokeratin-19 in Breast Cancer Tissue Samples: A Comparison of Automatic and Manual Evaluations of Scanned Tissue Microarray Cylinders

    Callau, C, Lejeune, M, Korzynska, A, García, M, Bueno, G, Bosch, R, Jaén, J, Orero, G, Salvadó, T, López, C. 01/01/2014. Proceedings Iwbbio 2014: International Work-Conference On Bioinformatics And Biomedical Engineering, Vols 1 And 2

    Prevalence of Undiagnosed Atrial Fibrillation and of That Not Being Treated With Anticoagulant Drugs: the AFABE Study

    Clua-Espuny, JL, Lechuga-Duran, I, Bosch-Princep, R, Roso-Llorach, A, Panisello-Tafalla, A, Lucas-Noll, J, López-Pablo, C, Queralt-Tomas, L, Giménez-Garcia, M, González-Rojas, N, López, MG. 01/07/2013. REVISTA ESPANOLA DE CARDIOLOGIA. 66. PMID: 24776203. doi: 10.1016/j.rec.2013.03.003

    Is It Necessary to Evaluate Nuclei in HER2 FISH Evaluation?

    López, C, Tomás, B, Korzynska, A, Bosch, R, Salvadó, MT, Llobera, M, Garcia-Rojo, M, Alvaro, T, Jaén, J, Lejeune, M. 01/01/2013. American Journal Of Clinical Pathology. 139. PMID: 23270898. doi: 10.1309/AJCPPXLYJVFGOV8I

    Antibody Response to Merkel Cell Polyomavirus Associated with Incident Lymphoma in the Epilymph Case-Control Study in Spain

    Robles, C, Poloczek, A, Casabonne, D, Gonzalez-Barca, E, Bosch, R, Benavente, Y, Viscidi, RP, de Sanjos, S. 01/09/2012. Cancer Epidemiology Biomarkers & Prevention. 21. PMID: 22781028. doi: 10.1158/1055-9965.EPI-11-1140

    Depression in the elderly: study in a rural city in southern Catalonia

    Montesó, P, Ferre, C, Lleixa, M, Albacar, N, Aguilar, C, Sanchez, A, Lejeune, M. 01/06/2012. Journal Of Psychiatric And Mental Health Nursing. 19. PMID: 22070581. doi: 10.1111/j.1365-2850.2011.01798.x

    Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients with sepsis treated in an intensive care unit: a preliminary report

    Sans, T, Rull, A, Luna, J, Mackness, B, Mackness, M, Joven, J, Ibañez, M, Pariente, R, Rodriguez, M, Ortin, X, Masdeu, G, Camps, J. 01/01/2012. Clinical Chemistry And Laboratory Medicine. 50. PMID: 22868806. doi: 10.1515/cclm-2011-0896

    Lipid-lowering drugs in ischaemic heart disease: A quasi-experimental uncontrolled before-and-after study of the effectiveness of clinical practice guidelines

    Dalmau, R, Boira, M, Aguilar, C, López, C, Rodríguez, D, Gentille, D, Bofill, D, Diogene, E, Pepio, JM. 04/08/2011. Bmc Cardiovascular Disorders. 11. PMID: 21816068. doi: 10.1186/1471-2261-11-47

    JPEG2000 for automated quantification of immunohistochemically stained cell nuclei: a comparative study with standard JPEG format

    Lejeune, M, López, C, Bosch, R, Korzynska, A, Salvadó, MT, García-Rojo, M, Neuman, U, Witkowski, L, Baucells, J, Jaén, J. 01/02/2011. Virchows Archiv. 458. PMID: 21085985. doi: 10.1007/s00428-010-1008-3

    Performance of the digene LQ, RH and PS HPVs genotyping systems on clinical samples and comparison with HC2 and PCR-based Linear Array

    Godínez, JM, Tous, S, Baixeras, N, Moreno-Crespi, J, Alejo, M, Lejeune, M, Bravo, IG, Bosch, FX, de Sanjosé, S. 01/01/2011. Infectious Agents And Cancer. 6. PMID: 22093164. doi: 10.1186/1750-9378-6-23

    Prostatic blue nevus. An infrequent histologic diagnosis

    Marti-Mestre, J, Cañis-Sánchez, D, Jaén-Martínez, JM, Princep, RB. 01/11/2010. Actas Urologicas Espanolas. 34. PMID: 21159289. doi: 10.1016/j.acuro.2010.03.040

    Roundness variation in JPEG images affects the automated process of nuclear immunohistochemical quantification: correction with a linear regression model

    López, C, Martinez, JJ, Lejeune, M, Escrivà, P, Salvadó, MT, Pons, LE, Alvaro, T, Baucells, J, García-Rojo, M, Cugat, X, Bosch, R. 01/10/2009. Histochemistry And Cell Biology. 132. PMID: 19652993. doi: 10.1007/s00418-009-0626-9

Membres De L’equip

  • Responsable de grup, PhD

    • Marylène Lejeune
    • Carlos López Pablo

  • Investigador clínic

    • Ramon Bosch Príncep
    • Tomàs Alvaro Naranjo
    • Montserrat Llobera Serentill
    • Xavier Ortín Font
    • Marta Rodríguez Luaces
    • Daniel Mata Cano
    • Antonio Rizo Barrios
    • Mª Teresa Giménez Pérez

  • Tècnics de laboratori

    • Bàrbara Tomàs Arasa
    • Vanessa Gestí García
    • Anna Curto Subirats
    • Noelia Burgués Llaó
    • Anna Suñé Martín
    • Eduard Nolla Villalonga
    • Almudena Nàgera Porres
    • Maria del Mar Barberà Marro
    • Beatriu Domènech Grau
    • Marc Iniesta Valldepérez
    • Maria Cinta Curto Anoll
    • Ana Guasch Bosch
    • Monsterrat Salvado Piñol
    • Ainhoa Montserrat Fontanet

  • Tècnics de recerca i informàtica

    • Jordi Baucells Lluís
    • Esther Sauras Colon
    • Júlia Casanova Ribes

  • Col·laboradors externs

    • Anna Korzynska
    • Benoît Plancoulaine
    • Nicolas Elie
    • Gloria Bueno
    • Domènec Puig Valls
    • Marcial García-Rojo
    • Gustavo Marrero Callico

Altres grups de Grups Clínics

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